Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes

Yoshiyuki Kimura, Hiromichi Okuda, Takuo Okuda, Tsutomu Hatano, Shigeru Arichi

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

As part of a series of biological examinations of various tannins and related compounds, the present paper reports the effects of caffeetannins and related compounds isolated from medicinal plants on arachidonate metabolism in human peripheral polymorphonuclear leukocytes (PMN-L). The formation of leukotriene B4(LTB4) induced by calcium ionophore A 23187 (A 23187) in human PMN-L was inhibited by 3,5-, 4,5-, and 3,4-di-O-caffeoylquinic acid, caffeoylmalic acid, caffeoyltartric acid, rosmarinic acid, and caffeic acid. Rosmarinic acid strongly inhibited the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) and LTB4(5-lipoxygenase products) at concentrations of 10-5-10-3M. On the other hand, the formation of prostaglandin E2(PGE2) was enhanced in a concentration-dependent fashion by caffeic acid, caf-feoylmalic acid, caffeoyltartaric acid, and 3,4-di-O-caffeoylquinic acid. On the basis of experimental results, it seems likely that caffeoyl derivatives could be developed as therapeutic drugs for treatment of allergic inflammation such as asthma.

Original languageEnglish
Pages (from-to)392-399
Number of pages8
JournalJournal of Natural Products
Volume50
Issue number3
DOIs
Publication statusPublished - May 1 1987

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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