Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)

Yoshiyuki Kimura, Hiromichi Okuda, Takuo Okuda, Takashi Yoshida, Tsutomu Hatano, Shigeru Arichi

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The effects of various tannins and related compounds on the actions of adrenocorticotropic hormone (ACTH) and insulin in fat cells isolated from rats were investigated. Hydrolyzable tannins such as geraniin, mallotusinic acid, chebulinic acid and chebulagic acid enhanced the ACTH-induced lipolysis at the concentration of 20μg /ml or 5 μg/ml. On the other hand, these hydrolyzable tannins had no effect on the insulin-stimulated lipogenesis from glucose. Condensed tannins such as Ss-tannin 1 and RSF-tannin H showed weak inhibitory effects on the ACTH-induced lipolysis, while they enhanced the insulin-stimulated lipogenesis from glucose. Based on these results, the relationship between the structures and physiological actions of these tannins is discussed.

Original languageEnglish
Pages (from-to)2501-2506
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume31
Issue number7
DOIs
Publication statusPublished - Jan 1 1983

Keywords

  • ACTH-induced lipolysis
  • condensed tannin
  • fat cell
  • hydrolyzable tannin
  • insulin-induced lipogenesis
  • medicinal plant
  • rat

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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