Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)

Yoshiyuki Kimura; Hiromichi Okuda; Takuo Okuda; Takashi Yoshida; Tsutomu Hatano; Shigeru Arichi

doi:10.1248/cpb.31.2501

Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)

Yoshiyuki Kimura, Hiromichi Okuda, Takuo Okuda, Takashi Yoshida, Tsutomu Hatano, Shigeru Arichi

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The effects of various tannins and related compounds on the actions of adrenocorticotropic hormone (ACTH) and insulin in fat cells isolated from rats were investigated. Hydrolyzable tannins such as geraniin, mallotusinic acid, chebulinic acid and chebulagic acid enhanced the ACTH-induced lipolysis at the concentration of 20μg /ml or 5 μg/ml. On the other hand, these hydrolyzable tannins had no effect on the insulin-stimulated lipogenesis from glucose. Condensed tannins such as Ss-tannin 1 and RSF-tannin H showed weak inhibitory effects on the ACTH-induced lipolysis, while they enhanced the insulin-stimulated lipogenesis from glucose. Based on these results, the relationship between the structures and physiological actions of these tannins is discussed.

Original language	English
Pages (from-to)	2501-2506
Number of pages	6
Journal	Chemical and Pharmaceutical Bulletin
Volume	31
Issue number	7
DOIs	https://doi.org/10.1248/cpb.31.2501
Publication status	Published - Jan 1 1983

Keywords

ACTH-induced lipolysis
condensed tannin
fat cell
hydrolyzable tannin
insulin-induced lipogenesis
medicinal plant
rat

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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Kimura, Y., Okuda, H., Okuda, T., Yoshida, T., Hatano, T., & Arichi, S. (1983). Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2). Chemical and Pharmaceutical Bulletin, 31(7), 2501-2506. https://doi.org/10.1248/cpb.31.2501

Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2). / Kimura, Yoshiyuki; Okuda, Hiromichi; Okuda, Takuo; Yoshida, Takashi; Hatano, Tsutomu; Arichi, Shigeru.

In: Chemical and Pharmaceutical Bulletin, Vol. 31, No. 7, 01.01.1983, p. 2501-2506.

Research output: Contribution to journal › Article › peer-review

Kimura, Y, Okuda, H, Okuda, T, Yoshida, T, Hatano, T & Arichi, S 1983, 'Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)', Chemical and Pharmaceutical Bulletin, vol. 31, no. 7, pp. 2501-2506. https://doi.org/10.1248/cpb.31.2501

Kimura Y, Okuda H, Okuda T, Yoshida T, Hatano T, Arichi S. Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2). Chemical and Pharmaceutical Bulletin. 1983 Jan 1;31(7):2501-2506. https://doi.org/10.1248/cpb.31.2501

Kimura, Yoshiyuki ; Okuda, Hiromichi ; Okuda, Takuo ; Yoshida, Takashi ; Hatano, Tsutomu ; Arichi, Shigeru. / Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2). In: Chemical and Pharmaceutical Bulletin. 1983 ; Vol. 31, No. 7. pp. 2501-2506.

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