Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)

Yoshiyuki Kimura; Hiromichi Okuda; Takuo Okuda; Takashi Yoshida; Tsutomu Hatano; Shigeru Arichi

doi:10.1248/cpb.31.2501

Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)

Yoshiyuki Kimura, Hiromichi Okuda, Takuo Okuda, Takashi Yoshida, Tsutomu Hatano, Shigeru Arichi

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The effects of various tannins and related compounds on the actions of adrenocorticotropic hormone (ACTH) and insulin in fat cells isolated from rats were investigated. Hydrolyzable tannins such as geraniin, mallotusinic acid, chebulinic acid and chebulagic acid enhanced the ACTH-induced lipolysis at the concentration of 20μg /ml or 5 μg/ml. On the other hand, these hydrolyzable tannins had no effect on the insulin-stimulated lipogenesis from glucose. Condensed tannins such as Ss-tannin 1 and RSF-tannin H showed weak inhibitory effects on the ACTH-induced lipolysis, while they enhanced the insulin-stimulated lipogenesis from glucose. Based on these results, the relationship between the structures and physiological actions of these tannins is discussed.

Original language	English
Pages (from-to)	2501-2506
Number of pages	6
Journal	Chemical and Pharmaceutical Bulletin
Volume	31
Issue number	7
DOIs	https://doi.org/10.1248/cpb.31.2501
Publication status	Published - Jan 1 1983

Keywords

ACTH-induced lipolysis
condensed tannin
fat cell
hydrolyzable tannin
insulin-induced lipogenesis
medicinal plant
rat

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.31.2501

Fingerprint

Dive into the research topics of 'Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)'. Together they form a unique fingerprint.

Cite this

Kimura, Y., Okuda, H., Okuda, T., Yoshida, T., Hatano, T., & Arichi, S. (1983). Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2). Chemical and Pharmaceutical Bulletin, 31(7), 2501-2506. https://doi.org/10.1248/cpb.31.2501

Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2). / Kimura, Yoshiyuki; Okuda, Hiromichi; Okuda, Takuo et al.

In: Chemical and Pharmaceutical Bulletin, Vol. 31, No. 7, 01.01.1983, p. 2501-2506.

Research output: Contribution to journal › Article › peer-review

Kimura, Y, Okuda, H, Okuda, T, Yoshida, T, Hatano, T & Arichi, S 1983, 'Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)', Chemical and Pharmaceutical Bulletin, vol. 31, no. 7, pp. 2501-2506. https://doi.org/10.1248/cpb.31.2501

Kimura Y, Okuda H, Okuda T, Yoshida T, Hatano T, Arichi S. Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2). Chemical and Pharmaceutical Bulletin. 1983 Jan 1;31(7):2501-2506. https://doi.org/10.1248/cpb.31.2501

Kimura, Yoshiyuki ; Okuda, Hiromichi ; Okuda, Takuo et al. / Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2). In: Chemical and Pharmaceutical Bulletin. 1983 ; Vol. 31, No. 7. pp. 2501-2506.

@article{5c17013103c34983b0096aeff466f612,

title = "Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)",

abstract = "The effects of various tannins and related compounds on the actions of adrenocorticotropic hormone (ACTH) and insulin in fat cells isolated from rats were investigated. Hydrolyzable tannins such as geraniin, mallotusinic acid, chebulinic acid and chebulagic acid enhanced the ACTH-induced lipolysis at the concentration of 20μg /ml or 5 μg/ml. On the other hand, these hydrolyzable tannins had no effect on the insulin-stimulated lipogenesis from glucose. Condensed tannins such as Ss-tannin 1 and RSF-tannin H showed weak inhibitory effects on the ACTH-induced lipolysis, while they enhanced the insulin-stimulated lipogenesis from glucose. Based on these results, the relationship between the structures and physiological actions of these tannins is discussed.",

keywords = "ACTH-induced lipolysis, condensed tannin, fat cell, hydrolyzable tannin, insulin-induced lipogenesis, medicinal plant, rat",

author = "Yoshiyuki Kimura and Hiromichi Okuda and Takuo Okuda and Takashi Yoshida and Tsutomu Hatano and Shigeru Arichi",

year = "1983",

month = jan,

day = "1",

doi = "10.1248/cpb.31.2501",

language = "English",

volume = "31",

pages = "2501--2506",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "7",

}

TY - JOUR

T1 - Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)

AU - Kimura, Yoshiyuki

AU - Okuda, Hiromichi

AU - Okuda, Takuo

AU - Yoshida, Takashi

AU - Hatano, Tsutomu

AU - Arichi, Shigeru

PY - 1983/1/1

Y1 - 1983/1/1

N2 - The effects of various tannins and related compounds on the actions of adrenocorticotropic hormone (ACTH) and insulin in fat cells isolated from rats were investigated. Hydrolyzable tannins such as geraniin, mallotusinic acid, chebulinic acid and chebulagic acid enhanced the ACTH-induced lipolysis at the concentration of 20μg /ml or 5 μg/ml. On the other hand, these hydrolyzable tannins had no effect on the insulin-stimulated lipogenesis from glucose. Condensed tannins such as Ss-tannin 1 and RSF-tannin H showed weak inhibitory effects on the ACTH-induced lipolysis, while they enhanced the insulin-stimulated lipogenesis from glucose. Based on these results, the relationship between the structures and physiological actions of these tannins is discussed.

AB - The effects of various tannins and related compounds on the actions of adrenocorticotropic hormone (ACTH) and insulin in fat cells isolated from rats were investigated. Hydrolyzable tannins such as geraniin, mallotusinic acid, chebulinic acid and chebulagic acid enhanced the ACTH-induced lipolysis at the concentration of 20μg /ml or 5 μg/ml. On the other hand, these hydrolyzable tannins had no effect on the insulin-stimulated lipogenesis from glucose. Condensed tannins such as Ss-tannin 1 and RSF-tannin H showed weak inhibitory effects on the ACTH-induced lipolysis, while they enhanced the insulin-stimulated lipogenesis from glucose. Based on these results, the relationship between the structures and physiological actions of these tannins is discussed.

KW - ACTH-induced lipolysis

KW - condensed tannin

KW - fat cell

KW - hydrolyzable tannin

KW - insulin-induced lipogenesis

KW - medicinal plant

KW - rat

UR - http://www.scopus.com/inward/record.url?scp=0020785281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020785281&partnerID=8YFLogxK

U2 - 10.1248/cpb.31.2501

DO - 10.1248/cpb.31.2501

M3 - Article

C2 - 6315250

AN - SCOPUS:0020785281

VL - 31

SP - 2501

EP - 2506

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 7

ER -

Studies on the Activities of Tannins and Related compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this