Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. I. Inhibitory Effects on Lipid Peroxidation in Mitochondria and Microsomes of Liver

Takuo Okuda, Takashi Yoshida, Tsutomu Hatano, Yoshiyuki Kimura, Hiromichi Okuda, Shigeru Arichi

Research output: Contribution to journalArticle

275 Citations (Scopus)

Abstract

The inhibitory effects of 25 tannins and related compounds on the lipid peroxidation induced by adenine 5'-diphosphate (ADP) and ascorbic acid in rat liver mitochondria, and on that induced in rat liver microsomes by ADP and nicotinamide adenine dinucleotide phosphate (NADPH), were determined. All of the tannins, except for some polyphenols of low molecular weight and methylated polyphenols, showed significant inhibition in these two systems at the concentration of 1 μg/ml. Almost complete inhibition of the lipid peroxidation in the two systems was shown by some ellagitannins such as pedunculagin, isoterchebin, etc., at, the dose of 5 μg/ml. Marked differences of the inhibitory activities were observed among the tannins depending on the tannin structure, including the stereoisomerism in the monomer of condensed tannin, and on the experimental system used. The inhibitory effects of most of the hydrolyzable tannins were higher than those of the condensed tannins in both systems. Some monomeric polyphenols, represented by (-)-epigallocatechin gallate, showed inhibitory effects stronger than those of the condensed tannins in these systems, particularly on the lipid peroxidation induced by ADP and NADPH. The inhibitory effects of these tannins in both systems were very much stronger than that of α-toconhcrol.

Original languageEnglish
Pages (from-to)1625-1631
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume31
Issue number5
DOIs
Publication statusPublished - Jan 1 1983

Keywords

  • ADP
  • NADPH
  • ascorbic acid
  • conrdensed tannin
  • ellagitannin
  • hydrolyzable tannin
  • inhibition
  • lipid peroxidation
  • structure-activity correlation
  • tannin

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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