Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VII. Effects of Extracts of Leaves of Artemisia Species, and Caffeic Acid and Chlorogenic Acid on Lipid Metabolic Injury in Rats Fed Peroxidized Oil

Yoshiyuki Kimura, Hiromichi Okuda, Takuo Okuda, Tsutomu Hatano, Isao Agata, Shigeru Arichi

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

The effects of oral administration of the extracts from the leaves of several Artemisia species, and of chlorogenic acid, which is one of their components, and also of caffeic acid (which can be produced by partial hydrolysis of caffeoylquinic acids, which are the main polyphenolic components in these species) on lipid metabolic injury produced in rats by feeding peroxidized oil were investigated. The acetone-water extracts of the leaves of Artemisia princeps, A. montana and A. capillaris reduced the elevation of lipid peroxide concentration in the serum in peroxidized oil-fed rats, and the above extracts reduced the levels of liver triglyceride. The extracts of A. montana and A. capillaris inhibited the elevation of serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase. Caffeic acid and chlorogenic acid also inhibited the elevation of serum triglyceride, lipid peroxides, total cholesterol, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase, as well as liver lipid peroxide.

Original languageEnglish
Pages (from-to)2028-2034
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume33
Issue number5
DOIs
Publication statusPublished - Jan 1 1985

Keywords

  • A. capillaris
  • A. montana
  • Artemisia princeps
  • caffeetannin
  • caffeic acid
  • chlorogenic acid
  • lipid metabolism
  • liver injury
  • tannin

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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