Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI.1) Inhibitory Effects of Cafifeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells

Yoshiyuki Kimur; Hiromichi Okuda; Takuo Okuda; Tsutomu Hatano; Isao Agata; Shigeru Arichi

doi:10.1248/cpb.33.690

Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI.¹⁾ Inhibitory Effects of Cafifeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells

Yoshiyuki Kimur, Hiromichi Okuda, Takuo Okuda, Tsutomu Hatano, Isao Agata, Shigeru Arichi

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

The inhibitory effects of caffeoylquinic acids isolated from the leaves of Artemisia species on the histamine release from rat mast cells induced by compound 48/80, and on that induced by concanavalin A plus phosphatidylserine were determined. At the concentration of 2.5 x 10^-5m,caffeic acid, chlorogenic acid and methyl chlorogenate exhibited over 50% inhibition of the histamine secretion induced by compound 48/80 from mast cells. The inhibitory effects of caffeic acid and monocaffeoylquinic acids (chlorogenic acid and methyl chlorogenate) were higher than those of dicaffeoylquinic acids on the compound 48/80-induced histamine release from mast cells. On the other hand, caffeic acid, chlorogenic acid and 3,5-di-O-caffeoylquinic acid exhibited over 50% inhibition of the histamine secretion induced by concanavalin A plus phosphatidylserine from mast cells at the concentration of 10^-5m.

Original language	English
Pages (from-to)	690-696
Number of pages	7
Journal	Chemical and Pharmaceutical Bulletin
Volume	33
Issue number	2
DOIs	https://doi.org/10.1248/cpb.33.690
Publication status	Published - Jan 1 1985

Keywords

artemisia montana
artemisia princeps
compositae
compound 48/80
concanavalin A
histamine
mast cell
phosphatidylserine
structure-activity correlation
tannin

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI.¹⁾ Inhibitory Effects of Cafifeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells. / Kimur, Yoshiyuki; Okuda, Hiromichi; Okuda, Takuo; Hatano, Tsutomu; Agata, Isao; Arichi, Shigeru.

In: Chemical and Pharmaceutical Bulletin, Vol. 33, No. 2, 01.01.1985, p. 690-696.

Research output: Contribution to journal › Article › peer-review

Kimur, Yoshiyuki ; Okuda, Hiromichi ; Okuda, Takuo ; Hatano, Tsutomu ; Agata, Isao ; Arichi, Shigeru. / Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI.¹⁾ Inhibitory Effects of Cafifeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells. In: Chemical and Pharmaceutical Bulletin. 1985 ; Vol. 33, No. 2. pp. 690-696.

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abstract = "The inhibitory effects of caffeoylquinic acids isolated from the leaves of Artemisia species on the histamine release from rat mast cells induced by compound 48/80, and on that induced by concanavalin A plus phosphatidylserine were determined. At the concentration of 2.5 x 10-5m,caffeic acid, chlorogenic acid and methyl chlorogenate exhibited over 50% inhibition of the histamine secretion induced by compound 48/80 from mast cells. The inhibitory effects of caffeic acid and monocaffeoylquinic acids (chlorogenic acid and methyl chlorogenate) were higher than those of dicaffeoylquinic acids on the compound 48/80-induced histamine release from mast cells. On the other hand, caffeic acid, chlorogenic acid and 3,5-di-O-caffeoylquinic acid exhibited over 50% inhibition of the histamine secretion induced by concanavalin A plus phosphatidylserine from mast cells at the concentration of 10-5m.",

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