Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI.1) Inhibitory Effects of Cafifeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells

Yoshiyuki Kimur; Hiromichi Okuda; Takuo Okuda; Tsutomu Hatano; Isao Agata; Shigeru Arichi

doi:10.1248/cpb.33.690

Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI.¹⁾ Inhibitory Effects of Cafifeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells

Yoshiyuki Kimur, Hiromichi Okuda, Takuo Okuda, Tsutomu Hatano, Isao Agata, Shigeru Arichi

Research output: Contribution to journal › Article

50 Citations (Scopus)

Abstract

The inhibitory effects of caffeoylquinic acids isolated from the leaves of Artemisia species on the histamine release from rat mast cells induced by compound 48/80, and on that induced by concanavalin A plus phosphatidylserine were determined. At the concentration of 2.5 x 10^-5m,caffeic acid, chlorogenic acid and methyl chlorogenate exhibited over 50% inhibition of the histamine secretion induced by compound 48/80 from mast cells. The inhibitory effects of caffeic acid and monocaffeoylquinic acids (chlorogenic acid and methyl chlorogenate) were higher than those of dicaffeoylquinic acids on the compound 48/80-induced histamine release from mast cells. On the other hand, caffeic acid, chlorogenic acid and 3,5-di-O-caffeoylquinic acid exhibited over 50% inhibition of the histamine secretion induced by concanavalin A plus phosphatidylserine from mast cells at the concentration of 10^-5m.

Original language	English
Pages (from-to)	690-696
Number of pages	7
Journal	Chemical and Pharmaceutical Bulletin
Volume	33
Issue number	2
DOIs	https://doi.org/10.1248/cpb.33.690
Publication status	Published - Jan 1 1985

Keywords

artemisia montana
artemisia princeps
compositae
compound 48/80
concanavalin A
histamine
mast cell
phosphatidylserine
structure-activity correlation
tannin

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.33.690

Fingerprint Dive into the research topics of 'Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI.<sup>1)</sup> Inhibitory Effects of Cafifeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells'. Together they form a unique fingerprint.

Cite this

Kimur, Y., Okuda, H., Okuda, T., Hatano, T., Agata, I., & Arichi, S. (1985). Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI.¹⁾ Inhibitory Effects of Cafifeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells. Chemical and Pharmaceutical Bulletin, 33(2), 690-696. https://doi.org/10.1248/cpb.33.690

Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI.¹⁾ Inhibitory Effects of Cafifeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells. / Kimur, Yoshiyuki; Okuda, Hiromichi; Okuda, Takuo; Hatano, Tsutomu; Agata, Isao; Arichi, Shigeru.

In: Chemical and Pharmaceutical Bulletin, Vol. 33, No. 2, 01.01.1985, p. 690-696.

Research output: Contribution to journal › Article

Kimur, Yoshiyuki ; Okuda, Hiromichi ; Okuda, Takuo ; Hatano, Tsutomu ; Agata, Isao ; Arichi, Shigeru. / Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI.¹⁾ Inhibitory Effects of Cafifeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells. In: Chemical and Pharmaceutical Bulletin. 1985 ; Vol. 33, No. 2. pp. 690-696.

@article{735ea28b3673485d80ce5bdb7c778ffc,

title = "Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI.1) Inhibitory Effects of Cafifeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells",

abstract = "The inhibitory effects of caffeoylquinic acids isolated from the leaves of Artemisia species on the histamine release from rat mast cells induced by compound 48/80, and on that induced by concanavalin A plus phosphatidylserine were determined. At the concentration of 2.5 x 10-5m,caffeic acid, chlorogenic acid and methyl chlorogenate exhibited over 50% inhibition of the histamine secretion induced by compound 48/80 from mast cells. The inhibitory effects of caffeic acid and monocaffeoylquinic acids (chlorogenic acid and methyl chlorogenate) were higher than those of dicaffeoylquinic acids on the compound 48/80-induced histamine release from mast cells. On the other hand, caffeic acid, chlorogenic acid and 3,5-di-O-caffeoylquinic acid exhibited over 50% inhibition of the histamine secretion induced by concanavalin A plus phosphatidylserine from mast cells at the concentration of 10-5m.",

keywords = "artemisia montana, artemisia princeps, compositae, compound 48/80, concanavalin A, histamine, mast cell, phosphatidylserine, structure-activity correlation, tannin",

author = "Yoshiyuki Kimur and Hiromichi Okuda and Takuo Okuda and Tsutomu Hatano and Isao Agata and Shigeru Arichi",

year = "1985",

month = jan,

day = "1",

doi = "10.1248/cpb.33.690",

language = "English",

volume = "33",

pages = "690--696",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "2",

}

TY - JOUR

T1 - Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI.1) Inhibitory Effects of Cafifeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells

AU - Kimur, Yoshiyuki

AU - Okuda, Hiromichi

AU - Okuda, Takuo

AU - Hatano, Tsutomu

AU - Agata, Isao

AU - Arichi, Shigeru

PY - 1985/1/1

Y1 - 1985/1/1

N2 - The inhibitory effects of caffeoylquinic acids isolated from the leaves of Artemisia species on the histamine release from rat mast cells induced by compound 48/80, and on that induced by concanavalin A plus phosphatidylserine were determined. At the concentration of 2.5 x 10-5m,caffeic acid, chlorogenic acid and methyl chlorogenate exhibited over 50% inhibition of the histamine secretion induced by compound 48/80 from mast cells. The inhibitory effects of caffeic acid and monocaffeoylquinic acids (chlorogenic acid and methyl chlorogenate) were higher than those of dicaffeoylquinic acids on the compound 48/80-induced histamine release from mast cells. On the other hand, caffeic acid, chlorogenic acid and 3,5-di-O-caffeoylquinic acid exhibited over 50% inhibition of the histamine secretion induced by concanavalin A plus phosphatidylserine from mast cells at the concentration of 10-5m.

AB - The inhibitory effects of caffeoylquinic acids isolated from the leaves of Artemisia species on the histamine release from rat mast cells induced by compound 48/80, and on that induced by concanavalin A plus phosphatidylserine were determined. At the concentration of 2.5 x 10-5m,caffeic acid, chlorogenic acid and methyl chlorogenate exhibited over 50% inhibition of the histamine secretion induced by compound 48/80 from mast cells. The inhibitory effects of caffeic acid and monocaffeoylquinic acids (chlorogenic acid and methyl chlorogenate) were higher than those of dicaffeoylquinic acids on the compound 48/80-induced histamine release from mast cells. On the other hand, caffeic acid, chlorogenic acid and 3,5-di-O-caffeoylquinic acid exhibited over 50% inhibition of the histamine secretion induced by concanavalin A plus phosphatidylserine from mast cells at the concentration of 10-5m.

KW - artemisia montana

KW - artemisia princeps

KW - compositae

KW - compound 48/80

KW - concanavalin A

KW - histamine

KW - mast cell

KW - phosphatidylserine

KW - structure-activity correlation

KW - tannin

UR - http://www.scopus.com/inward/record.url?scp=0021871273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021871273&partnerID=8YFLogxK

U2 - 10.1248/cpb.33.690

DO - 10.1248/cpb.33.690

M3 - Article

C2 - 2410155

AN - SCOPUS:0021871273

VL - 33

SP - 690

EP - 696

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 2

ER -