Abstract
The inhibitory effects of caffeoylquinic acids isolated from the leaves of Artemisia species on the histamine release from rat mast cells induced by compound 48/80, and on that induced by concanavalin A plus phosphatidylserine were determined. At the concentration of 2.5 x 10-5m,caffeic acid, chlorogenic acid and methyl chlorogenate exhibited over 50% inhibition of the histamine secretion induced by compound 48/80 from mast cells. The inhibitory effects of caffeic acid and monocaffeoylquinic acids (chlorogenic acid and methyl chlorogenate) were higher than those of dicaffeoylquinic acids on the compound 48/80-induced histamine release from mast cells. On the other hand, caffeic acid, chlorogenic acid and 3,5-di-O-caffeoylquinic acid exhibited over 50% inhibition of the histamine secretion induced by concanavalin A plus phosphatidylserine from mast cells at the concentration of 10-5m.
Original language | English |
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Pages (from-to) | 690-696 |
Number of pages | 7 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 33 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jan 1 1985 |
Keywords
- artemisia montana
- artemisia princeps
- compositae
- compound 48/80
- concanavalin A
- histamine
- mast cell
- phosphatidylserine
- structure-activity correlation
- tannin
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery