Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation

Takahiro Kataoka, Akihiro Sakoda, Masaaki Yoshimoto, Shinya Nakagawa, Teruaki Toyota, Yuichi Nishiyama, Keiko Yamato, Yuu Ishimori, Atsushi Kawabe, Katsumi Hanamoto, Takehito Taguchi, Kiyonori Yamaoka

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4 Citations (Scopus)

Abstract

Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl4) administration. Results showed that radon inhalation alleviates CCl4-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.

Original languageEnglish
Article numberncr189
Pages (from-to)360-363
Number of pages4
JournalRadiation Protection Dosimetry
Volume146
Issue number1-3
DOIs
Publication statusPublished - Jul 2011

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation
  • Public Health, Environmental and Occupational Health

Cite this

Kataoka, T., Sakoda, A., Yoshimoto, M., Nakagawa, S., Toyota, T., Nishiyama, Y., Yamato, K., Ishimori, Y., Kawabe, A., Hanamoto, K., Taguchi, T., & Yamaoka, K. (2011). Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation. Radiation Protection Dosimetry, 146(1-3), 360-363. [ncr189]. https://doi.org/10.1093/rpd/ncr189