Abstract
Some properties and mechanism of action of a hemolysin (VMH) produced by an enteropathogenic Vibrio mimicus strain was examined. VMH was heat‐labile and inhibited by addition of divalent cations, including Ca2+, Mg2+ and Mn2+. The hemolysis by VMH was inhibited by incubating with gangliosides, suggesting that the ganglioside was the binding site on the erythrocyte membrane for VMH. Existence of a galactose moiety on reducing end of the ganglioside molecule and a sialic acid on the galactose moiety was suggested to be important for the binding of VMH molecule. Colloid osmotic manner of the hemolysis by VMH was demonstrated.
Original language | English |
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Pages (from-to) | 405-409 |
Number of pages | 5 |
Journal | MICROBIOLOGY and IMMUNOLOGY |
Volume | 37 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 1993 |
Keywords
- gangliosides
- hemolysin
- vibrio mimicus
ASJC Scopus subject areas
- Microbiology
- Immunology
- Virology