Studies On Drug Absorption from Oral Cavity: Physico-Chemical Factors Affecting Absorption from Hamster Cheek Pouch

Yuji Kurosaki, Noriko Aya, Yumiko Okada, Taiji Nakayama, Toshikiro Kimura

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

A new experimental method using a hamster cheek pouch in vivo for studying absorption processes across the keratinized oral mucous membrane was developed and some characteristics of the oral-mucosal absorption were clarified. A possitive correlation between the absorption rate and the lipophilicity was observed in 18 aromatic compounds examined. The absorption of ionizable compounds was poor in the ionized form. These results suggest that the absorption from the keratinized hamster cheek pouch is due to a passive diffusion mechanism and obeys pH-partition hypothesis. The systemic transfer of salicylic acid after intra-cheek-pouch administration could be approximated by the first-order absorption model including a lag time process and the plasma levels found were consistent with this model.

Original languageEnglish
Pages (from-to)287-296
Number of pages10
Journaljournal of pharmacobio-dynamics
Volume9
Issue number3
DOIs
Publication statusPublished - 1986

Keywords

  • absorption
  • hamster cheek pouch
  • oral mucosa
  • pharmacokinetics
  • physico-chemical factor
  • salicylic acid

ASJC Scopus subject areas

  • Pharmacology

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