Studies of the mechanism of action of the aerolysin-like hemolysin of Aeromonas sobria in stimulating T84 cells to produce cyclic AMP

Yoshio Fujii, Tomohiko Nomura, Ritsuko Yokoyama, Sumio Shinoda, Keinosuke Okamoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We previously reported that the aerolysin-like hemolysin of Aeromonas sobria stimulates T84 cells to produce cyclic AMP, which then emerges in the culture medium. In order to clarify the mechanism of action of the hemolysin, we examined the involvement of adenosine nucleotide. The results show that the hemolysin stimulates T84 cells to release ATP, which is then converted to adenosine by ectonucleotidase. The adenosine generated might stimulate the P1 adenosine receptors of T84 cells to produce cyclic AMP.

Original languageEnglish
Pages (from-to)1557-1560
Number of pages4
JournalInfection and Immunity
Volume71
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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