Strychnine-enhanced transsynaptic degeneration of dorsal horn neurons in rats with an experimental painful peripheral neuropathy

T. Sugimoto, G. J. Bennett, K. C. Kajander

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

A painful peripheral neuropathy was produced by loosely tying constrictive ligatures around the sciatic nerve of rats. Eight days after the nerve injury and after a series of injections with a subconvulsive dose of strychnine, the animals were sacrificed and the spinal cord dorsal horn was examined for signs of transsynaptic degeneration. The presence of strychnine-enhanced transsynaptic degeneration was apparent from the presence of many pyknotic and hyperchromatic neurons (dark neurons). The dark neurons were seen in laminae I-IV bilaterally, but they were significantly more frequent ipsilateral to the nerve injury. The majority of the dark neurons were found within the medial two-thirds of laminae I-II; this region corresponds to the intraspinal territory of the sciatic nerve's small diameter afferents. The results suggest that a peripheral nerve injury that produces neuropathic pain induces morphological alterations of intraspinal somatosensory circuitry.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalNeuroscience Letters
Volume98
Issue number2
DOIs
Publication statusPublished - Mar 27 1989
Externally publishedYes

Fingerprint

Posterior Horn Cells
Strychnine
Peripheral Nervous System Diseases
Neurons
Sciatic Nerve
Peripheral Nerve Injuries
Wounds and Injuries
Neuralgia
Ligation
Injections
Painful Neuropathy
Spinal Cord Dorsal Horn

Keywords

  • Nerve injury
  • Peripheral neuropathy
  • Spinal dorsal horn
  • Strychnine
  • Transsynaptic degeneration

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Strychnine-enhanced transsynaptic degeneration of dorsal horn neurons in rats with an experimental painful peripheral neuropathy. / Sugimoto, T.; Bennett, G. J.; Kajander, K. C.

In: Neuroscience Letters, Vol. 98, No. 2, 27.03.1989, p. 139-143.

Research output: Contribution to journalArticle

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