Strychnine and l-allylglycine but not bicuculline and picrotoxin induce transsynaptic degeneration following transection of the inferior alveolar nerve in adult rats

Tomosada Sugimoto, Motohide Takemura, Johji Okubo, Akira Sakai

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effects of the convulsants strychnine, bicuculline, picrotoxin and l-allylglycine on the transsynaptic destruction of medullary dorsal horn neurons were examined following transection of the inferior alveolar nerve in adult rats. Strychnine and l-allylglycine enhanced the transsynaptic effect of nerve transection and caused degeneration of many dorsal horn neurons, while bicuculline and picrotoxin did not. The removal of glycinergic and GABAergic postsynaptic inhibition appears to enhance the transsynaptic destructive activity which follows the peripheral nerve transection.

Original languageEnglish
Pages (from-to)393-398
Number of pages6
JournalBrain Research
Volume341
Issue number2
DOIs
Publication statusPublished - Aug 26 1985

Keywords

  • l-allylglycine
  • medullarly dorsal horn
  • peripheral nerve injury
  • strychnine
  • transsynaptic degeneration

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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