Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant enterococcus species

Eerdunbayaer, Mohamed A.A. Orabi, Hiroe Aoyama, Teruo Kuroda, Tsutomu Hatano

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds. Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.

Original languageEnglish
Pages (from-to)3883-3897
Number of pages15
JournalMolecules
Volume19
Issue number4
DOIs
Publication statusPublished - Apr 2014

Keywords

  • 2-arylcoumarone
  • 3-arylcoumarin
  • Antibacterial effect
  • Flavonoid
  • Glycyrrhiza uralensis
  • Licorice
  • Phenolics
  • VRE

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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