Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant enterococcus species

Eerdunbayaer, Mohamed A A Orabi, Hiroe Aoyama, Teruo Kuroda, Tsutomu Hatano

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds. Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.

Original languageEnglish
Pages (from-to)3883-3897
Number of pages15
JournalMolecules
Volume19
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Glycyrrhiza
Methicillin
Vancomycin
Flavonoids
Methicillin-Resistant Staphylococcus aureus
Oxacillin
staphylococcus
Bacteria
bacteria
examination
Vancomycin-Resistant Enterococci
glycycoumarin

Keywords

  • 2-arylcoumarone
  • 3-arylcoumarin
  • Antibacterial effect
  • Flavonoid
  • Glycyrrhiza uralensis
  • Licorice
  • Phenolics
  • VRE

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

Cite this

Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant enterococcus species. / Eerdunbayaer; Orabi, Mohamed A A; Aoyama, Hiroe; Kuroda, Teruo; Hatano, Tsutomu.

In: Molecules, Vol. 19, No. 4, 2014, p. 3883-3897.

Research output: Contribution to journalArticle

Eerdunbayaer ; Orabi, Mohamed A A ; Aoyama, Hiroe ; Kuroda, Teruo ; Hatano, Tsutomu. / Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant enterococcus species. In: Molecules. 2014 ; Vol. 19, No. 4. pp. 3883-3897.
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