Structure-function relationships in the Mn4CaO5 water-splitting cluster

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Citations (Scopus)

    Abstract

    Mn4CaO5 cluster is the catalytic center for photosynthetic water-splitting harbored in photosystem II (PSII), a huge, multi-subunit membrane- protein complex located in the thylakoid membranes from cyanobacteria to higher plants. The structure of PSII has been analyzed at 1.9 Å resolution by X-ray crystallography, revealing a clear picture of the Mn4CaO5 cluster. In this chapter, principles of crystallization and crystal structure analysis are briefly introduced, followed by descriptions of the structure of the Mn4CaO5 cluster and its implications in the mechanism of water-splitting. Based on the geometric organization of the Mn4CaO5 cluster, the location of four terminal water ligands, the possible oxidation states of the four Mn ions reported so far, as well as the structural changes revealed by replacing the Ca ion with Sr, a mechanism for water-splitting was proposed and discussed.

    Original languageEnglish
    Title of host publicationThe Biophysics of Photosynthesis
    PublisherSpringer New York
    Pages321-349
    Number of pages29
    ISBN (Electronic)9781493911486
    ISBN (Print)9781493911479
    DOIs
    Publication statusPublished - Jan 1 2014

    Keywords

    • Crystal structure
    • Crystallization
    • Membrane proteins
    • Oxygen evolution
    • Photosynthesis
    • Photosystem II
    • S-state

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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