Structure, Function, and Drug Interactions of Neurotransmitter Transporters in the Postgenomic Era

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Vesicular neurotransmitter transporters are responsible for the accumulation of neurotransmitters in secretory vesicles and play essential roles in chemical transmission. The SLC17 family contributes to sequestration of anionic neurotransmitters such as glutamate, aspartate, and nucleotides. Identification and subsequent cellular and molecular biological studies of SLC17 transporters unveiled the principles underlying the actions of these transporters. Recent progress in reconstitution methods in combination with postgenomic approaches has advanced studies on neurotransmitter transporters. This review summarizes the molecular properties of SLC17-type transporters and recent findings regarding the novel SLC18 transporter.

Original languageEnglish
Pages (from-to)385-402
Number of pages18
JournalAnnual Review of Pharmacology and Toxicology
Volume56
DOIs
Publication statusPublished - Jan 6 2016

Keywords

  • Purification
  • Reconstitution
  • SLC17
  • Transporter
  • Vesicular neurotransmitter transporter

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Fingerprint Dive into the research topics of 'Structure, Function, and Drug Interactions of Neurotransmitter Transporters in the Postgenomic Era'. Together they form a unique fingerprint.

  • Cite this