Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

Akiyuki Ikedo; Ichiro Hayakawa; Takeo Usui; Sayaka Kazami; Hiroyuki Osada; Hideo Kigoshi

doi:10.1016/j.bmcl.2010.07.111

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S₃ cells

Akiyuki Ikedo, Ichiro Hayakawa, Takeo Usui, Sayaka Kazami, Hiroyuki Osada, Hideo Kigoshi

Faculty of Engineering

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S₃ cells was investigated. Compared to glaziovianin A, the O⁷-allyl derivative was found to be more cytotoxic against HeLa S₃ cells and a more potent M-phase inhibitor.

Original language	English
Pages (from-to)	5402-5404
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2010.07.111
Publication status	Published - Sep 15 2010

Keywords

Antitumor activity
Glaziovianin A
Isoflavone
Structure-activity relationship study

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2010.07.111

Fingerprint Dive into the research topics of 'Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S<sub>3</sub> cells'. Together they form a unique fingerprint.

Cite this

Ikedo, A., Hayakawa, I., Usui, T., Kazami, S., Osada, H., & Kigoshi, H. (2010). Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S₃ cells. Bioorganic and Medicinal Chemistry Letters, 20(18), 5402-5404. https://doi.org/10.1016/j.bmcl.2010.07.111

@article{bdf4278c4d274666b4eca51eda810cb7,

title = "Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells",

abstract = "Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.",

keywords = "Antitumor activity, Glaziovianin A, Isoflavone, Structure-activity relationship study",

author = "Akiyuki Ikedo and Ichiro Hayakawa and Takeo Usui and Sayaka Kazami and Hiroyuki Osada and Hideo Kigoshi",

year = "2010",

month = sep,

day = "15",

doi = "10.1016/j.bmcl.2010.07.111",

language = "English",

volume = "20",

pages = "5402--5404",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "18",

}

TY - JOUR

T1 - Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

AU - Ikedo, Akiyuki

AU - Hayakawa, Ichiro

AU - Usui, Takeo

AU - Kazami, Sayaka

AU - Osada, Hiroyuki

AU - Kigoshi, Hideo

PY - 2010/9/15

Y1 - 2010/9/15

N2 - Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.

AB - Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.

KW - Antitumor activity

KW - Glaziovianin A

KW - Isoflavone

KW - Structure-activity relationship study

UR - http://www.scopus.com/inward/record.url?scp=77956179682&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956179682&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2010.07.111

DO - 10.1016/j.bmcl.2010.07.111

M3 - Article

C2 - 20719506

AN - SCOPUS:77956179682

VL - 20

SP - 5402

EP - 5404

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 18

ER -