Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

Akiyuki Ikedo, Ichiro Hayakawa, Takeo Usui, Sayaka Kazami, Hiroyuki Osada, Hideo Kigoshi

Research output: Contribution to journal › Article

15 Citations (Scopus)

Abstract

Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.

Original languageEnglish
Pages (from-to)5402-5404
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number18
DOIs
Publication statusPublished - Sep 15 2010
Externally publishedYes

Fingerprint

Structure-Activity Relationship
HeLa Cells
Cell Cycle
Cells
Derivatives
Isoflavones
Cytotoxicity
Cell Division
glaziovianin A

Keywords

  • Antitumor activity
  • Glaziovianin A
  • Isoflavone
  • Structure-activity relationship study

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells. / Ikedo, Akiyuki; Hayakawa, Ichiro; Usui, Takeo; Kazami, Sayaka; Osada, Hiroyuki; Kigoshi, Hideo.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 18, 15.09.2010, p. 5402-5404.

Research output: Contribution to journal › Article

Ikedo, A, Hayakawa, I, Usui, T, Kazami, S, Osada, H & Kigoshi, H 2010, 'Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells', Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 18, pp. 5402-5404. https://doi.org/10.1016/j.bmcl.2010.07.111
Ikedo A, Hayakawa I, Usui T, Kazami S, Osada H, Kigoshi H. Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells. Bioorganic and Medicinal Chemistry Letters. 2010 Sep 15;20(18):5402-5404. https://doi.org/10.1016/j.bmcl.2010.07.111
Ikedo, Akiyuki ; Hayakawa, Ichiro ; Usui, Takeo ; Kazami, Sayaka ; Osada, Hiroyuki ; Kigoshi, Hideo. / Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 18. pp. 5402-5404.
@article{bdf4278c4d274666b4eca51eda810cb7,
title = "Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells",
abstract = "Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.",
keywords = "Antitumor activity, Glaziovianin A, Isoflavone, Structure-activity relationship study",
author = "Akiyuki Ikedo and Ichiro Hayakawa and Takeo Usui and Sayaka Kazami and Hiroyuki Osada and Hideo Kigoshi",
year = "2010",
month = "9",
day = "15",
doi = "10.1016/j.bmcl.2010.07.111",
language = "English",
volume = "20",
pages = "5402--5404",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "18",

}

TY - JOUR

T1 - Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

AU - Ikedo, Akiyuki

AU - Hayakawa, Ichiro

AU - Usui, Takeo

AU - Kazami, Sayaka

AU - Osada, Hiroyuki

AU - Kigoshi, Hideo

PY - 2010/9/15

Y1 - 2010/9/15

N2 - Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.

AB - Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.

KW - Antitumor activity

KW - Glaziovianin A

KW - Isoflavone

KW - Structure-activity relationship study

UR - http://www.scopus.com/inward/record.url?scp=77956179682&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956179682&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2010.07.111

DO - 10.1016/j.bmcl.2010.07.111

M3 - Article

C2 - 20719506

AN - SCOPUS:77956179682

VL - 20

SP - 5402

EP - 5404

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 18

ER -

Access to Document