Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

Akiyuki Ikedo, Ichiro Hayakawa, Takeo Usui, Sayaka Kazami, Hiroyuki Osada, Hideo Kigoshi

Research output: Contribution to journal › Article

15 Citations (Scopus)

Abstract

Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.

Original languageEnglish
Pages (from-to)5402-5404
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number18
DOIs
Publication statusPublished - Sep 15 2010
Externally publishedYes

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Structure-Activity Relationship
HeLa Cells
Cell Cycle
Cells
Derivatives
Isoflavones
Cytotoxicity
Cell Division
glaziovianin A

Keywords

  • Antitumor activity
  • Glaziovianin A
  • Isoflavone
  • Structure-activity relationship study

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells. / Ikedo, Akiyuki; Hayakawa, Ichiro; Usui, Takeo; Kazami, Sayaka; Osada, Hiroyuki; Kigoshi, Hideo.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 18, 15.09.2010, p. 5402-5404.

Research output: Contribution to journal › Article

Ikedo, A, Hayakawa, I, Usui, T, Kazami, S, Osada, H & Kigoshi, H 2010, 'Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells', Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 18, pp. 5402-5404. https://doi.org/10.1016/j.bmcl.2010.07.111
Ikedo A, Hayakawa I, Usui T, Kazami S, Osada H, Kigoshi H. Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells. Bioorganic and Medicinal Chemistry Letters. 2010 Sep 15;20(18):5402-5404. https://doi.org/10.1016/j.bmcl.2010.07.111
Ikedo, Akiyuki ; Hayakawa, Ichiro ; Usui, Takeo ; Kazami, Sayaka ; Osada, Hiroyuki ; Kigoshi, Hideo. / Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 18. pp. 5402-5404.
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