Abstract
Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.
Original language | English |
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Pages (from-to) | 5402-5404 |
Number of pages | 3 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 20 |
Issue number | 18 |
DOIs | |
Publication status | Published - Sep 15 2010 |
Keywords
- Antitumor activity
- Glaziovianin A
- Isoflavone
- Structure-activity relationship study
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry