Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

Akiyuki Ikedo; Ichiro Hayakawa; Takeo Usui; Sayaka Kazami; Hiroyuki Osada; Hideo Kigoshi

doi:10.1016/j.bmcl.2010.07.111

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S₃ cells

Akiyuki Ikedo, Ichiro Hayakawa, Takeo Usui, Sayaka Kazami, Hiroyuki Osada, Hideo Kigoshi

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S₃ cells was investigated. Compared to glaziovianin A, the O⁷-allyl derivative was found to be more cytotoxic against HeLa S₃ cells and a more potent M-phase inhibitor.

Original language	English
Pages (from-to)	5402-5404
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2010.07.111
Publication status	Published - Sep 15 2010
Externally published	Yes

Keywords

Antitumor activity
Glaziovianin A
Isoflavone
Structure-activity relationship study

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2010.07.111

Cite this

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S₃ cells. / Ikedo, Akiyuki; Hayakawa, Ichiro; Usui, Takeo; Kazami, Sayaka; Osada, Hiroyuki; Kigoshi, Hideo.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 18, 15.09.2010, p. 5402-5404.

Research output: Contribution to journal › Article › peer-review

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AU - Kigoshi, Hideo

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