Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

Akiyuki Ikedo; Ichiro Hayakawa; Takeo Usui; Sayaka Kazami; Hiroyuki Osada; Hideo Kigoshi

doi:10.1016/j.bmcl.2010.07.111

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

Akiyuki Ikedo, Ichiro Hayakawa, Takeo Usui, Sayaka Kazami, Hiroyuki Osada, Hideo Kigoshi

Research output: Contribution to journal › Article

15 Citations (Scopus)

Abstract

Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S₃ cells was investigated. Compared to glaziovianin A, the O⁷-allyl derivative was found to be more cytotoxic against HeLa S₃ cells and a more potent M-phase inhibitor.

Original language	English
Pages (from-to)	5402-5404
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2010.07.111
Publication status	Published - Sep 15 2010
Externally published	Yes

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Keywords

Antitumor activity
Glaziovianin A
Isoflavone
Structure-activity relationship study

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Organic Chemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry
Biochemistry

Cite this

Ikedo, A., Hayakawa, I., Usui, T., Kazami, S., Osada, H., & Kigoshi, H. (2010). Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells. Bioorganic and Medicinal Chemistry Letters, 20(18), 5402-5404. https://doi.org/10.1016/j.bmcl.2010.07.111

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AU - Kazami, Sayaka

AU - Osada, Hiroyuki

AU - Kigoshi, Hideo

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Access to Document

10.1016/j.bmcl.2010.07.111