Structure-activity relationship of indoloquinoline analogs anti-MRSA

Min Zhao, Tomonori Kamada, Aya Takeuchi, Hiromi Nishioka, Teruo Kuroda, Yasuo Takeuchi

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.

Original languageEnglish
Pages (from-to)5551-5554
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number23
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Structure-Activity Relationship
Methicillin-Resistant Staphylococcus aureus
Quinolines
Methicillin
Phenol
quinoline
4-aminophenol

Keywords

  • Anti-MRSA
  • Benzofuroquinoline
  • Indenoquinoline
  • Indoloquinoline
  • Structure-activity

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Structure-activity relationship of indoloquinoline analogs anti-MRSA. / Zhao, Min; Kamada, Tomonori; Takeuchi, Aya; Nishioka, Hiromi; Kuroda, Teruo; Takeuchi, Yasuo.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 25, No. 23, 01.12.2015, p. 5551-5554.

Research output: Contribution to journal › Article

Zhao, M, Kamada, T, Takeuchi, A, Nishioka, H, Kuroda, T & Takeuchi, Y 2015, 'Structure-activity relationship of indoloquinoline analogs anti-MRSA', Bioorganic and Medicinal Chemistry Letters, vol. 25, no. 23, pp. 5551-5554. https://doi.org/10.1016/j.bmcl.2015.10.058
Zhao M, Kamada T, Takeuchi A, Nishioka H, Kuroda T, Takeuchi Y. Structure-activity relationship of indoloquinoline analogs anti-MRSA. Bioorganic and Medicinal Chemistry Letters. 2015 Dec 1;25(23):5551-5554. https://doi.org/10.1016/j.bmcl.2015.10.058
Zhao, Min ; Kamada, Tomonori ; Takeuchi, Aya ; Nishioka, Hiromi ; Kuroda, Teruo ; Takeuchi, Yasuo. / Structure-activity relationship of indoloquinoline analogs anti-MRSA. In: Bioorganic and Medicinal Chemistry Letters. 2015 ; Vol. 25, No. 23. pp. 5551-5554.
@article{e94de17b1f264731a8ee4f3850422600,
title = "Structure-activity relationship of indoloquinoline analogs anti-MRSA",
abstract = "Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.",
keywords = "Anti-MRSA, Benzofuroquinoline, Indenoquinoline, Indoloquinoline, Structure-activity",
author = "Min Zhao and Tomonori Kamada and Aya Takeuchi and Hiromi Nishioka and Teruo Kuroda and Yasuo Takeuchi",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.bmcl.2015.10.058",
language = "English",
volume = "25",
pages = "5551--5554",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "23",

}

TY - JOUR

T1 - Structure-activity relationship of indoloquinoline analogs anti-MRSA

AU - Zhao, Min

AU - Kamada, Tomonori

AU - Takeuchi, Aya

AU - Nishioka, Hiromi

AU - Kuroda, Teruo

AU - Takeuchi, Yasuo

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.

AB - Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.

KW - Anti-MRSA

KW - Benzofuroquinoline

KW - Indenoquinoline

KW - Indoloquinoline

KW - Structure-activity

UR - http://www.scopus.com/inward/record.url?scp=84946575605&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946575605&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2015.10.058

DO - 10.1016/j.bmcl.2015.10.058

M3 - Article

VL - 25

SP - 5551

EP - 5554

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 23

ER -

Access to Document