Structure-activity relationship of indoloquinoline analogs anti-MRSA

Min Zhao; Tomonori Kamada; Aya Takeuchi; Hiromi Nishioka; Teruo Kuroda; Yasuo Takeuchi

doi:10.1016/j.bmcl.2015.10.058

Structure-activity relationship of indoloquinoline analogs anti-MRSA

Min Zhao, Tomonori Kamada, Aya Takeuchi, Hiromi Nishioka, Teruo Kuroda, Yasuo Takeuchi

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.

Original language	English
Pages (from-to)	5551-5554
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2015.10.058
Publication status	Published - Dec 1 2015

Keywords

Anti-MRSA
Benzofuroquinoline
Indenoquinoline
Indoloquinoline
Structure-activity

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Structure-activity relationship of indoloquinoline analogs anti-MRSA",

abstract = "Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.",

keywords = "Anti-MRSA, Benzofuroquinoline, Indenoquinoline, Indoloquinoline, Structure-activity",

author = "Min Zhao and Tomonori Kamada and Aya Takeuchi and Hiromi Nishioka and Teruo Kuroda and Yasuo Takeuchi",

note = "Funding Information: This work was supported by Graduate School of Medicine , Dentistry and Pharmaceutical Sciences , Okayama University and the SC-NMR laboratory of Okayama University for using of the facilities. The authors are grateful to Ms. Megumi Kosaka and Mr. Motonari Kobayashi at Division of Instrumental Analysis for the measurements of elemental analyses, and the MS measurements. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd. All rights reserved. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2015",

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doi = "10.1016/j.bmcl.2015.10.058",

language = "English",

volume = "25",

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T1 - Structure-activity relationship of indoloquinoline analogs anti-MRSA

AU - Zhao, Min

AU - Kamada, Tomonori

AU - Takeuchi, Aya

AU - Nishioka, Hiromi

AU - Kuroda, Teruo

AU - Takeuchi, Yasuo

N1 - Funding Information: This work was supported by Graduate School of Medicine , Dentistry and Pharmaceutical Sciences , Okayama University and the SC-NMR laboratory of Okayama University for using of the facilities. The authors are grateful to Ms. Megumi Kosaka and Mr. Motonari Kobayashi at Division of Instrumental Analysis for the measurements of elemental analyses, and the MS measurements. Publisher Copyright: © 2015 Elsevier Ltd. All rights reserved. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.

AB - Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.

KW - Anti-MRSA

KW - Benzofuroquinoline

KW - Indenoquinoline

KW - Indoloquinoline

KW - Structure-activity

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

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ER -

Structure-activity relationship of indoloquinoline analogs anti-MRSA

Abstract

Keywords

ASJC Scopus subject areas

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