Structure-activity relationship of indoloquinoline analogs anti-MRSA

Min Zhao; Tomonori Kamada; Aya Takeuchi; Hiromi Nishioka; Teruo Kuroda; Yasuo Takeuchi

doi:10.1016/j.bmcl.2015.10.058

Structure-activity relationship of indoloquinoline analogs anti-MRSA

Min Zhao, Tomonori Kamada, Aya Takeuchi, Hiromi Nishioka, Teruo Kuroda, Yasuo Takeuchi

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.

Original language	English
Pages (from-to)	5551-5554
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2015.10.058
Publication status	Published - Dec 1 2015

Keywords

Anti-MRSA
Benzofuroquinoline
Indenoquinoline
Indoloquinoline
Structure-activity

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Structure-activity relationship of indoloquinoline analogs anti-MRSA",

abstract = "Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.",

keywords = "Anti-MRSA, Benzofuroquinoline, Indenoquinoline, Indoloquinoline, Structure-activity",

author = "Min Zhao and Tomonori Kamada and Aya Takeuchi and Hiromi Nishioka and Teruo Kuroda and Yasuo Takeuchi",

year = "2015",

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T1 - Structure-activity relationship of indoloquinoline analogs anti-MRSA

AU - Zhao, Min

AU - Kamada, Tomonori

AU - Takeuchi, Aya

AU - Nishioka, Hiromi

AU - Kuroda, Teruo

AU - Takeuchi, Yasuo

PY - 2015/12/1

Y1 - 2015/12/1

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AB - Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.

KW - Anti-MRSA

KW - Benzofuroquinoline

KW - Indenoquinoline

KW - Indoloquinoline

KW - Structure-activity

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