Structure-activity relationship of indoloquinoline analogs anti-MRSA

Min Zhao, Tomonori Kamada, Aya Takeuchi, Hiromi Nishioka, Teruo Kuroda, Yasuo Takeuchi

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.

Original languageEnglish
Pages (from-to)5551-5554
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number23
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Anti-MRSA
  • Benzofuroquinoline
  • Indenoquinoline
  • Indoloquinoline
  • Structure-activity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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