Abstract
Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.
| Original language | English |
|---|---|
| Pages (from-to) | 5551-5554 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 25 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - Dec 1 2015 |
Keywords
- Anti-MRSA
- Benzofuroquinoline
- Indenoquinoline
- Indoloquinoline
- Structure-activity
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Cite this
Zhao, M., Kamada, T., Takeuchi, A., Nishioka, H., Kuroda, T., & Takeuchi, Y. (2015). Structure-activity relationship of indoloquinoline analogs anti-MRSA. Bioorganic and Medicinal Chemistry Letters, 25(23), 5551-5554. https://doi.org/10.1016/j.bmcl.2015.10.058