Structural modification of isoalantolactone and biological activity against the hepatoma cell lines

Rui Xia Guo, Li Geng Li, Man Li Zhang, Françoise Sauriol, Qing Wen Shi, Yu Cheng Gu, Hiromasa Kiyota

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Abstract

Structural modifications were performed on isoalantolactone in an effort to find compounds with potential anticancer activity. Seven previously unknown adducts of active methylene compounds with isoalantolactone were synthesized by the Michael reaction. Moreover, four derivatives of aryl-substituted isoalantolactone were prepared by the Heck reaction. All synthetic products were evaluated for toxic activities against three different hepatoma cell lines, Bel-7402, SMMC-7721, and Hep G2. Products prepared through the Heck reaction and 3a,b show potential antiproliferative activity against the Hep G2 cell.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalHeterocyclic Communications
Volume20
Issue number2
DOIs
Publication statusPublished - Apr 2014

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Keywords

  • Antiproliferative activity
  • Heck reaction
  • Isoalantolactone
  • Michael reaction
  • Structural modification

ASJC Scopus subject areas

  • Organic Chemistry

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