Structural diversity of murine serum amyloid A genes

Evolutionary implications

Ken-ichi Yamamoto, N. Goto, J. Kosaka, M. Shiroo, Y. D. Yeul, S. Migita

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Mouse serum amyloid A (SAA) gene family comprises four members that are closely linked in the chromosome 7. Two of these genes encoding major mouse SAA isotypes (SAA1 and SAA2) are highly homologous not only in exons but also in introns and flanking regions; this sequence homology extends 280 base pairs upstream of major cap sites and 430 base pairs downstream of polyadenylation sites, and the 5' boundary of this homology unit is marked by the CA/GT repeat. Sequence comparison also shows that one (SAA4) of the other two genes is related to the SAA1/2 gene, whereas the other gene (SAA3) evolved independently. Based on these results and the SAA gene arrangement, we discussed mouse SAA gene evolution.

Original languageEnglish
Pages (from-to)1683-1688
Number of pages6
JournalJournal of Immunology
Volume139
Issue number5
Publication statusPublished - 1987
Externally publishedYes

Fingerprint

vif Genes
Amyloid
Serum Amyloid A Protein
Serum
Genes
Base Pairing
Polyadenylation
Chromosomes, Human, Pair 7
Gene Order
Sequence Homology
Introns
Exons

ASJC Scopus subject areas

  • Immunology

Cite this

Yamamoto, K., Goto, N., Kosaka, J., Shiroo, M., Yeul, Y. D., & Migita, S. (1987). Structural diversity of murine serum amyloid A genes: Evolutionary implications. Journal of Immunology, 139(5), 1683-1688.

Structural diversity of murine serum amyloid A genes : Evolutionary implications. / Yamamoto, Ken-ichi; Goto, N.; Kosaka, J.; Shiroo, M.; Yeul, Y. D.; Migita, S.

In: Journal of Immunology, Vol. 139, No. 5, 1987, p. 1683-1688.

Research output: Contribution to journalArticle

Yamamoto, K, Goto, N, Kosaka, J, Shiroo, M, Yeul, YD & Migita, S 1987, 'Structural diversity of murine serum amyloid A genes: Evolutionary implications', Journal of Immunology, vol. 139, no. 5, pp. 1683-1688.
Yamamoto K, Goto N, Kosaka J, Shiroo M, Yeul YD, Migita S. Structural diversity of murine serum amyloid A genes: Evolutionary implications. Journal of Immunology. 1987;139(5):1683-1688.
Yamamoto, Ken-ichi ; Goto, N. ; Kosaka, J. ; Shiroo, M. ; Yeul, Y. D. ; Migita, S. / Structural diversity of murine serum amyloid A genes : Evolutionary implications. In: Journal of Immunology. 1987 ; Vol. 139, No. 5. pp. 1683-1688.
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