Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis

Takashi Misawa; Hiroshi Aoyama; Taniyuki Furuyama; Kosuke Dodo; Morihiko Sagawa; Hiroyuki Miyachi; Masahiro Kizaki; Yuichi Hashimoto

doi:10.1248/cpb.56.1490

Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis

Takashi Misawa, Hiroshi Aoyama, Taniyuki Furuyama, Kosuke Dodo, Morihiko Sagawa, Hiroyuki Miyachi, Masahiro Kizaki, Yuichi Hashimoto

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC ₅₀ value of 0.12 μM.

Original language	English
Pages (from-to)	1490-1495
Number of pages	6
Journal	Chemical and Pharmaceutical Bulletin
Volume	56
Issue number	10
DOIs	https://doi.org/10.1248/cpb.56.1490
Publication status	Published - Oct 1 2008

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Keywords

1′-acetoxychavicol acetate
Benzhydrol analog
HL-60
Molecular operating environment
Quantitative structure-activity relationship

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Cite this

Misawa, T., Aoyama, H., Furuyama, T., Dodo, K., Sagawa, M., Miyachi, H., Kizaki, M., & Hashimoto, Y. (2008). Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis. Chemical and Pharmaceutical Bulletin, 56(10), 1490-1495. https://doi.org/10.1248/cpb.56.1490

Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis. / Misawa, Takashi; Aoyama, Hiroshi; Furuyama, Taniyuki; Dodo, Kosuke; Sagawa, Morihiko; Miyachi, Hiroyuki; Kizaki, Masahiro; Hashimoto, Yuichi.

In: Chemical and Pharmaceutical Bulletin, Vol. 56, No. 10, 01.10.2008, p. 1490-1495.

Research output: Contribution to journal › Article

Misawa, T, Aoyama, H, Furuyama, T, Dodo, K, Sagawa, M, Miyachi, H, Kizaki, M & Hashimoto, Y 2008, 'Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis', Chemical and Pharmaceutical Bulletin, vol. 56, no. 10, pp. 1490-1495. https://doi.org/10.1248/cpb.56.1490

Misawa, Takashi ; Aoyama, Hiroshi ; Furuyama, Taniyuki ; Dodo, Kosuke ; Sagawa, Morihiko ; Miyachi, Hiroyuki ; Kizaki, Masahiro ; Hashimoto, Yuichi. / Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis. In: Chemical and Pharmaceutical Bulletin. 2008 ; Vol. 56, No. 10. pp. 1490-1495.

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10.1248/cpb.56.1490