Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis

Takashi Misawa, Hiroshi Aoyama, Taniyuki Furuyama, Kosuke Dodo, Morihiko Sagawa, Hiroyuki Miyachi, Masahiro Kizaki, Yuichi Hashimoto

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC 50 value of 0.12 μM.

Original languageEnglish
Pages (from-to)1490-1495
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume56
Issue number10
DOIs
Publication statusPublished - Oct 2008
Externally publishedYes

Fingerprint

Growth Inhibitors
Quantitative Structure-Activity Relationship
HL-60 Cells
Cell growth
Leukemia
Growth
1'-acetoxychavicol acetate
benzohydrol

Keywords

  • 1′-acetoxychavicol acetate
  • Benzhydrol analog
  • HL-60
  • Molecular operating environment
  • Quantitative structure-activity relationship

ASJC Scopus subject areas

  • Drug Discovery
  • Chemistry(all)

Cite this

Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis. / Misawa, Takashi; Aoyama, Hiroshi; Furuyama, Taniyuki; Dodo, Kosuke; Sagawa, Morihiko; Miyachi, Hiroyuki; Kizaki, Masahiro; Hashimoto, Yuichi.

In: Chemical and Pharmaceutical Bulletin, Vol. 56, No. 10, 10.2008, p. 1490-1495.

Research output: Contribution to journal › Article

Misawa, T, Aoyama, H, Furuyama, T, Dodo, K, Sagawa, M, Miyachi, H, Kizaki, M & Hashimoto, Y 2008, 'Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis', Chemical and Pharmaceutical Bulletin, vol. 56, no. 10, pp. 1490-1495. https://doi.org/10.1248/cpb.56.1490
Misawa T, Aoyama H, Furuyama T, Dodo K, Sagawa M, Miyachi H et al. Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis. Chemical and Pharmaceutical Bulletin. 2008 Oct;56(10):1490-1495. https://doi.org/10.1248/cpb.56.1490
Misawa, Takashi ; Aoyama, Hiroshi ; Furuyama, Taniyuki ; Dodo, Kosuke ; Sagawa, Morihiko ; Miyachi, Hiroyuki ; Kizaki, Masahiro ; Hashimoto, Yuichi. / Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis. In: Chemical and Pharmaceutical Bulletin. 2008 ; Vol. 56, No. 10. pp. 1490-1495.
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