Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis

Takashi Misawa; Hiroshi Aoyama; Taniyuki Furuyama; Kosuke Dodo; Morihiko Sagawa; Hiroyuki Miyachi; Masahiro Kizaki; Yuichi Hashimoto

doi:10.1248/cpb.56.1490

Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis

Takashi Misawa, Hiroshi Aoyama, Taniyuki Furuyama, Kosuke Dodo, Morihiko Sagawa, Hiroyuki Miyachi, Masahiro Kizaki, Yuichi Hashimoto

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC ₅₀ value of 0.12 μM.

Original language	English
Pages (from-to)	1490-1495
Number of pages	6
Journal	Chemical and Pharmaceutical Bulletin
Volume	56
Issue number	10
DOIs	https://doi.org/10.1248/cpb.56.1490
Publication status	Published - Oct 2008

Keywords

1′-acetoxychavicol acetate
Benzhydrol analog
HL-60
Molecular operating environment
Quantitative structure-activity relationship

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.56.1490

Cite this

Misawa, T., Aoyama, H., Furuyama, T., Dodo, K., Sagawa, M., Miyachi, H., Kizaki, M., & Hashimoto, Y. (2008). Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis. Chemical and Pharmaceutical Bulletin, 56(10), 1490-1495. https://doi.org/10.1248/cpb.56.1490

Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis. / Misawa, Takashi; Aoyama, Hiroshi; Furuyama, Taniyuki; Dodo, Kosuke; Sagawa, Morihiko; Miyachi, Hiroyuki; Kizaki, Masahiro; Hashimoto, Yuichi.

In: Chemical and Pharmaceutical Bulletin, Vol. 56, No. 10, 10.2008, p. 1490-1495.

Research output: Contribution to journal › Article › peer-review

Misawa, T, Aoyama, H, Furuyama, T, Dodo, K, Sagawa, M, Miyachi, H, Kizaki, M & Hashimoto, Y 2008, 'Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis', Chemical and Pharmaceutical Bulletin, vol. 56, no. 10, pp. 1490-1495. https://doi.org/10.1248/cpb.56.1490

Misawa, Takashi ; Aoyama, Hiroshi ; Furuyama, Taniyuki ; Dodo, Kosuke ; Sagawa, Morihiko ; Miyachi, Hiroyuki ; Kizaki, Masahiro ; Hashimoto, Yuichi. / Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis. In: Chemical and Pharmaceutical Bulletin. 2008 ; Vol. 56, No. 10. pp. 1490-1495.

@article{1811386cd17e4eabab0cdb85fc32c9b7,

title = "Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis",

abstract = "Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC 50 value of 0.12 μM.",

keywords = "1′-acetoxychavicol acetate, Benzhydrol analog, HL-60, Molecular operating environment, Quantitative structure-activity relationship",

author = "Takashi Misawa and Hiroshi Aoyama and Taniyuki Furuyama and Kosuke Dodo and Morihiko Sagawa and Hiroyuki Miyachi and Masahiro Kizaki and Yuichi Hashimoto",

year = "2008",

month = oct,

doi = "10.1248/cpb.56.1490",

language = "English",

volume = "56",

pages = "1490--1495",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "10",

}

TY - JOUR

T1 - Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis

AU - Misawa, Takashi

AU - Aoyama, Hiroshi

AU - Furuyama, Taniyuki

AU - Dodo, Kosuke

AU - Sagawa, Morihiko

AU - Miyachi, Hiroyuki

AU - Kizaki, Masahiro

AU - Hashimoto, Yuichi

PY - 2008/10

Y1 - 2008/10

N2 - Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC 50 value of 0.12 μM.

AB - Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC 50 value of 0.12 μM.

KW - 1′-acetoxychavicol acetate

KW - Benzhydrol analog

KW - HL-60

KW - Molecular operating environment

KW - Quantitative structure-activity relationship

UR - http://www.scopus.com/inward/record.url?scp=54349112585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54349112585&partnerID=8YFLogxK

U2 - 10.1248/cpb.56.1490

DO - 10.1248/cpb.56.1490

M3 - Article

C2 - 18827399

AN - SCOPUS:54349112585

VL - 56

SP - 1490

EP - 1495

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 10

ER -

Structural development of benzhydrol-type 1′-Acetoxychavicol Acetate (ACA) analogs as human leukemia cell-growth inhibitors based on Quantitative Structure-Activity Relationship (QSAR) analysis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this