Abstract
Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC 50 value of 0.12 μM.
Original language | English |
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Pages (from-to) | 1490-1495 |
Number of pages | 6 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 56 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2008 |
Keywords
- 1′-acetoxychavicol acetate
- Benzhydrol analog
- HL-60
- Molecular operating environment
- Quantitative structure-activity relationship
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery