Structural changes and morphometric analysis of the pituitary gland after hemorrhage induced by intraperitoneal injection of hypertonic solution in mice

I. Koshimizu, N. Awamura, Sakae Takeuchi, Y. Kobayashi

Research output: Contribution to journalArticle

Abstract

Structural changes and changes in volume of three lobes of the pituitary gland and of degenerative regions of the anterior pituitary were investigated 3, 5, 7, 14, 21 and 28 days after pituitary hemorrhage induced by intraperitoneal injection of 9% NaCl solution at a dose of 0.03 ml/g body weight in mice. The necrotic changes in the anterior lobe was most extensive on day 3 of bleeding. A huge mass of necrosis was observed protruding into the distended hypophyseal lumen on days 5 to 7 of hemorrhage. On days 14 to 28, the cellular elements and necrotic debris in the lumen were almost eliminated. These findings suggest a new role for the hypophyseal lumen as a site of storage and digestion of waste materials migrated from the anterior pituitary. Among the three lobes of the pituitary gland, the anterior lobe decreased in volume after hemorrhage showing a minimum on day 14 (43.2% of the control) followed by a slight recovery on day 28 (50.1% of the control). This atrophy of the anterior pituitary after hemorrhage is ascribed to the shrinkage of necrosis and to the lack of regeneration of unaffected normal cells of the anterior lobe during the time examined.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalBiomedical Research
Volume13
Issue number4
Publication statusPublished - 1992

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Hypertonic Solutions
Pituitary Gland
Intraperitoneal Injections
Anterior Pituitary Gland
Hemorrhage
Debris
Recovery
Necrosis
Atrophy
Regeneration
Digestion
Body Weight

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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Structural changes and morphometric analysis of the pituitary gland after hemorrhage induced by intraperitoneal injection of hypertonic solution in mice. / Koshimizu, I.; Awamura, N.; Takeuchi, Sakae; Kobayashi, Y.

In: Biomedical Research, Vol. 13, No. 4, 1992, p. 253-258.

Research output: Contribution to journalArticle

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