Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger

Koji Abe, Satoshi Yuki, Kyuya Kogure

Research output: Contribution to journalArticle

339 Citations (Scopus)

Abstract

Regional changes in the amount of free fatty acids, polyphosphoinositides, and water content in the cerebral cortex were examined using a middle cerebral artery occlusion model of rats. The amount of various free fatty acids increased as polyphosphoinositides decreased during 3 and 6 hours of ischemia in the occluded middle cerebral artery territory. After 3 hours of reperfusion following 3 hours of ischemia, free fatty acids partially recovered while polyphosphoinositides did not. Water content increased significantly after 3 and 6 hours of ischemia, and a further increase was found after 3 hours of reperfusion following 3 hours of ischemia. The change of polyenoic fatty acids in this occluded middle cerebral artery territory was much smaller than that in the case of decapitation ischemia, although the amounts of polyphosphoinositides and monoenoic and saturated fatty acids showed almost identical changes in both cases, probably because polyenoic fatty acids may be washed out and/or peroxidatively consumed in the middle cerebral artery occlusion model due to its residual blood flow. Changes in the area surrounding the occluded middle cerebral artery territory were similar to the above results, although less dramatic However, there was no change in free fatty acids, polyphosphoinositides, and water content in the contralateral cortex. A novel free radical scavenger (MCI-186), which prevents both nonenzymatic peroxidation and lipoxygenase activity in vitro, markedly attenuated the ischemic and postischemk brain swelling. These results suggest that free radical mechanisms may be involved in ischemk and postischemic brain edema.

Original languageEnglish
Pages (from-to)480-485
Number of pages6
JournalStroke
Volume19
Issue number4
Publication statusPublished - 1988
Externally publishedYes

Fingerprint

Phosphatidylinositol Phosphates
Free Radical Scavengers
Brain Edema
Ischemia
Nonesterified Fatty Acids
Middle Cerebral Artery
Fatty Acids
Middle Cerebral Artery Infarction
Reperfusion
Water
Decapitation
Lipoxygenase
Cerebral Cortex
Free Radicals

Keywords

  • Abstract
  • Cerebral edema
  • Cerebral ischemia
  • Free radicals
  • Rats

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Neuroscience(all)

Cite this

Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. / Abe, Koji; Yuki, Satoshi; Kogure, Kyuya.

In: Stroke, Vol. 19, No. 4, 1988, p. 480-485.

Research output: Contribution to journalArticle

Abe, Koji ; Yuki, Satoshi ; Kogure, Kyuya. / Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. In: Stroke. 1988 ; Vol. 19, No. 4. pp. 480-485.
@article{990920dcc4324da397aecfd34acb4652,
title = "Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger",
abstract = "Regional changes in the amount of free fatty acids, polyphosphoinositides, and water content in the cerebral cortex were examined using a middle cerebral artery occlusion model of rats. The amount of various free fatty acids increased as polyphosphoinositides decreased during 3 and 6 hours of ischemia in the occluded middle cerebral artery territory. After 3 hours of reperfusion following 3 hours of ischemia, free fatty acids partially recovered while polyphosphoinositides did not. Water content increased significantly after 3 and 6 hours of ischemia, and a further increase was found after 3 hours of reperfusion following 3 hours of ischemia. The change of polyenoic fatty acids in this occluded middle cerebral artery territory was much smaller than that in the case of decapitation ischemia, although the amounts of polyphosphoinositides and monoenoic and saturated fatty acids showed almost identical changes in both cases, probably because polyenoic fatty acids may be washed out and/or peroxidatively consumed in the middle cerebral artery occlusion model due to its residual blood flow. Changes in the area surrounding the occluded middle cerebral artery territory were similar to the above results, although less dramatic However, there was no change in free fatty acids, polyphosphoinositides, and water content in the contralateral cortex. A novel free radical scavenger (MCI-186), which prevents both nonenzymatic peroxidation and lipoxygenase activity in vitro, markedly attenuated the ischemic and postischemk brain swelling. These results suggest that free radical mechanisms may be involved in ischemk and postischemic brain edema.",
keywords = "Abstract, Cerebral edema, Cerebral ischemia, Free radicals, Rats",
author = "Koji Abe and Satoshi Yuki and Kyuya Kogure",
year = "1988",
language = "English",
volume = "19",
pages = "480--485",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger

AU - Abe, Koji

AU - Yuki, Satoshi

AU - Kogure, Kyuya

PY - 1988

Y1 - 1988

N2 - Regional changes in the amount of free fatty acids, polyphosphoinositides, and water content in the cerebral cortex were examined using a middle cerebral artery occlusion model of rats. The amount of various free fatty acids increased as polyphosphoinositides decreased during 3 and 6 hours of ischemia in the occluded middle cerebral artery territory. After 3 hours of reperfusion following 3 hours of ischemia, free fatty acids partially recovered while polyphosphoinositides did not. Water content increased significantly after 3 and 6 hours of ischemia, and a further increase was found after 3 hours of reperfusion following 3 hours of ischemia. The change of polyenoic fatty acids in this occluded middle cerebral artery territory was much smaller than that in the case of decapitation ischemia, although the amounts of polyphosphoinositides and monoenoic and saturated fatty acids showed almost identical changes in both cases, probably because polyenoic fatty acids may be washed out and/or peroxidatively consumed in the middle cerebral artery occlusion model due to its residual blood flow. Changes in the area surrounding the occluded middle cerebral artery territory were similar to the above results, although less dramatic However, there was no change in free fatty acids, polyphosphoinositides, and water content in the contralateral cortex. A novel free radical scavenger (MCI-186), which prevents both nonenzymatic peroxidation and lipoxygenase activity in vitro, markedly attenuated the ischemic and postischemk brain swelling. These results suggest that free radical mechanisms may be involved in ischemk and postischemic brain edema.

AB - Regional changes in the amount of free fatty acids, polyphosphoinositides, and water content in the cerebral cortex were examined using a middle cerebral artery occlusion model of rats. The amount of various free fatty acids increased as polyphosphoinositides decreased during 3 and 6 hours of ischemia in the occluded middle cerebral artery territory. After 3 hours of reperfusion following 3 hours of ischemia, free fatty acids partially recovered while polyphosphoinositides did not. Water content increased significantly after 3 and 6 hours of ischemia, and a further increase was found after 3 hours of reperfusion following 3 hours of ischemia. The change of polyenoic fatty acids in this occluded middle cerebral artery territory was much smaller than that in the case of decapitation ischemia, although the amounts of polyphosphoinositides and monoenoic and saturated fatty acids showed almost identical changes in both cases, probably because polyenoic fatty acids may be washed out and/or peroxidatively consumed in the middle cerebral artery occlusion model due to its residual blood flow. Changes in the area surrounding the occluded middle cerebral artery territory were similar to the above results, although less dramatic However, there was no change in free fatty acids, polyphosphoinositides, and water content in the contralateral cortex. A novel free radical scavenger (MCI-186), which prevents both nonenzymatic peroxidation and lipoxygenase activity in vitro, markedly attenuated the ischemic and postischemk brain swelling. These results suggest that free radical mechanisms may be involved in ischemk and postischemic brain edema.

KW - Abstract

KW - Cerebral edema

KW - Cerebral ischemia

KW - Free radicals

KW - Rats

UR - http://www.scopus.com/inward/record.url?scp=0023947826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023947826&partnerID=8YFLogxK

M3 - Article

C2 - 2834836

AN - SCOPUS:0023947826

VL - 19

SP - 480

EP - 485

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 4

ER -