Stress affects a gastrin-releasing peptide system in the spinal cord that mediates sexual function: Implications for psychogenic erectile dysfunction

Hirotaka Sakamoto, Ken Ichi Matsuda, Damian G. Zuloaga, Nobuko Nishiura, Keiko Takanami, Cynthia L. Jordan, S. Marc Breedlove, Mitsuhiro Kawata

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Many men suffering from stress, including post-traumatic stress disorder (PTSD), report sexual dysfunction, which is traditionally treated via psychological counseling. Recently, we identified a gastrin-releasing peptide (GRP) system in the lumbar spinal cord that is a primary mediator for male reproductive functions. Methodology/Principal Findings: To ask whether an acute severe stress could alter the male specific GRP system, we used a single-prolonged stress (SPS), a putative rat model for PTSD in the present study. Exposure of SPS to male rats decreases both the local content and axonal distribution of GRP in the lower lumbar spinal cord and results in an attenuation of penile reflexes in vivo. Remarkably, pharmacological stimulation of GRP receptors restores penile reflexes in SPS-exposed males, and induces spontaneous ejaculation in a dose-dependent manner. Furthermore, although the level of plasma testosterone is normal 7 days after SPS exposure, we found a significant decrease in the expression of androgen receptor protein in this spinal center. Conclusions/Significance: We conclude that the spinal GRP system appears to be a stress-vulnerable center for male reproductive functions, which may provide new insight into a clinical target for the treatment of erectile dysfunction triggered by stress and psychiatric disorders.

Original languageEnglish
Article numbere4276
JournalPLoS One
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 26 2009
Externally publishedYes

Fingerprint

gastrin-releasing peptide
Gastrin-Releasing Peptide
Erectile Dysfunction
spinal cord
Spinal Cord
Post-Traumatic Stress Disorders
reflexes
Reflex
Bombesin Receptors
Ejaculation
behavior disorders
ejaculation
counseling
Androgen Receptors
Rats
testosterone
Psychiatry
Testosterone
Counseling
animal models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Stress affects a gastrin-releasing peptide system in the spinal cord that mediates sexual function : Implications for psychogenic erectile dysfunction. / Sakamoto, Hirotaka; Matsuda, Ken Ichi; Zuloaga, Damian G.; Nishiura, Nobuko; Takanami, Keiko; Jordan, Cynthia L.; Breedlove, S. Marc; Kawata, Mitsuhiro.

In: PLoS One, Vol. 4, No. 1, e4276, 26.01.2009.

Research output: Contribution to journalArticle

Sakamoto, Hirotaka ; Matsuda, Ken Ichi ; Zuloaga, Damian G. ; Nishiura, Nobuko ; Takanami, Keiko ; Jordan, Cynthia L. ; Breedlove, S. Marc ; Kawata, Mitsuhiro. / Stress affects a gastrin-releasing peptide system in the spinal cord that mediates sexual function : Implications for psychogenic erectile dysfunction. In: PLoS One. 2009 ; Vol. 4, No. 1.
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