Streptozotocin-induced diabetic pregnant rats exhibit signs and symptoms mimicking preeclampsia

Go Ishihara, Yuji Hiramatsu, Hisashi Masuyama, Takafumi Kudo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The number of patients with hypertension, obesity, diabetes, and hyperlipidemia is increasing. This tendency is observed in pregnant women, in whom many obstetrical and perinatal complications occur. The prevention of these abnormalities is important in reducing perinatal mortality and the risk of coronary disease. We established a pregnant rat model with diabetes and signs and symptoms mimicking preeclampsia. On day 6 of pregnancy, streptozotocin (STZ) or citrate buffer was injected into the tail vein. After STZ administration, plasma glucose was increased within 48 hours and sustained at a high level until day 20 of pregnancy, and plasma insulin was decreased. Fetuses from STZ-treated mothers were growth-restricted, and plasma glucose was 6-fold higher in fetuses of STZ-treated versus control rats. The systolic blood pressure, urinary protein, and hematocrit were increased significantly in STZ-treated rats. Total cholesterol and triglycerides were also elevated in STZ-treated rats, but plasma leptin levels were decreased. The STZ-induced diabetic pregnant rat model exhibited preeclampsia, hemoconcentration, hyperlipidemia, hypoleptinemia, and intrauterine growth restriction. This model closely mimics the features of human pregnancy complicated by diabetes and is useful for the basic study of the pathophysiology of pregnancy with diabetes. Copyright (C) 2000 by W.B. Saunders Company.

Original languageEnglish
Pages (from-to)853-857
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume49
Issue number7
DOIs
Publication statusPublished - Jul 2000

Fingerprint

Streptozocin
Pre-Eclampsia
Signs and Symptoms
Pregnancy
Hyperlipidemias
Fetus
Blood Pressure
Glucose
Perinatal Mortality
Growth
Leptin
Hematocrit
Citric Acid
Coronary Disease
Tail
Pregnant Women
Veins
Buffers
Triglycerides
Obesity

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Streptozotocin-induced diabetic pregnant rats exhibit signs and symptoms mimicking preeclampsia. / Ishihara, Go; Hiramatsu, Yuji; Masuyama, Hisashi; Kudo, Takafumi.

In: Metabolism: Clinical and Experimental, Vol. 49, No. 7, 07.2000, p. 853-857.

Research output: Contribution to journalArticle

@article{6a92a63afe644b519d57cf50769c88b7,
title = "Streptozotocin-induced diabetic pregnant rats exhibit signs and symptoms mimicking preeclampsia",
abstract = "The number of patients with hypertension, obesity, diabetes, and hyperlipidemia is increasing. This tendency is observed in pregnant women, in whom many obstetrical and perinatal complications occur. The prevention of these abnormalities is important in reducing perinatal mortality and the risk of coronary disease. We established a pregnant rat model with diabetes and signs and symptoms mimicking preeclampsia. On day 6 of pregnancy, streptozotocin (STZ) or citrate buffer was injected into the tail vein. After STZ administration, plasma glucose was increased within 48 hours and sustained at a high level until day 20 of pregnancy, and plasma insulin was decreased. Fetuses from STZ-treated mothers were growth-restricted, and plasma glucose was 6-fold higher in fetuses of STZ-treated versus control rats. The systolic blood pressure, urinary protein, and hematocrit were increased significantly in STZ-treated rats. Total cholesterol and triglycerides were also elevated in STZ-treated rats, but plasma leptin levels were decreased. The STZ-induced diabetic pregnant rat model exhibited preeclampsia, hemoconcentration, hyperlipidemia, hypoleptinemia, and intrauterine growth restriction. This model closely mimics the features of human pregnancy complicated by diabetes and is useful for the basic study of the pathophysiology of pregnancy with diabetes. Copyright (C) 2000 by W.B. Saunders Company.",
author = "Go Ishihara and Yuji Hiramatsu and Hisashi Masuyama and Takafumi Kudo",
year = "2000",
month = "7",
doi = "10.1053/meta.2000.6750",
language = "English",
volume = "49",
pages = "853--857",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "7",

}

TY - JOUR

T1 - Streptozotocin-induced diabetic pregnant rats exhibit signs and symptoms mimicking preeclampsia

AU - Ishihara, Go

AU - Hiramatsu, Yuji

AU - Masuyama, Hisashi

AU - Kudo, Takafumi

PY - 2000/7

Y1 - 2000/7

N2 - The number of patients with hypertension, obesity, diabetes, and hyperlipidemia is increasing. This tendency is observed in pregnant women, in whom many obstetrical and perinatal complications occur. The prevention of these abnormalities is important in reducing perinatal mortality and the risk of coronary disease. We established a pregnant rat model with diabetes and signs and symptoms mimicking preeclampsia. On day 6 of pregnancy, streptozotocin (STZ) or citrate buffer was injected into the tail vein. After STZ administration, plasma glucose was increased within 48 hours and sustained at a high level until day 20 of pregnancy, and plasma insulin was decreased. Fetuses from STZ-treated mothers were growth-restricted, and plasma glucose was 6-fold higher in fetuses of STZ-treated versus control rats. The systolic blood pressure, urinary protein, and hematocrit were increased significantly in STZ-treated rats. Total cholesterol and triglycerides were also elevated in STZ-treated rats, but plasma leptin levels were decreased. The STZ-induced diabetic pregnant rat model exhibited preeclampsia, hemoconcentration, hyperlipidemia, hypoleptinemia, and intrauterine growth restriction. This model closely mimics the features of human pregnancy complicated by diabetes and is useful for the basic study of the pathophysiology of pregnancy with diabetes. Copyright (C) 2000 by W.B. Saunders Company.

AB - The number of patients with hypertension, obesity, diabetes, and hyperlipidemia is increasing. This tendency is observed in pregnant women, in whom many obstetrical and perinatal complications occur. The prevention of these abnormalities is important in reducing perinatal mortality and the risk of coronary disease. We established a pregnant rat model with diabetes and signs and symptoms mimicking preeclampsia. On day 6 of pregnancy, streptozotocin (STZ) or citrate buffer was injected into the tail vein. After STZ administration, plasma glucose was increased within 48 hours and sustained at a high level until day 20 of pregnancy, and plasma insulin was decreased. Fetuses from STZ-treated mothers were growth-restricted, and plasma glucose was 6-fold higher in fetuses of STZ-treated versus control rats. The systolic blood pressure, urinary protein, and hematocrit were increased significantly in STZ-treated rats. Total cholesterol and triglycerides were also elevated in STZ-treated rats, but plasma leptin levels were decreased. The STZ-induced diabetic pregnant rat model exhibited preeclampsia, hemoconcentration, hyperlipidemia, hypoleptinemia, and intrauterine growth restriction. This model closely mimics the features of human pregnancy complicated by diabetes and is useful for the basic study of the pathophysiology of pregnancy with diabetes. Copyright (C) 2000 by W.B. Saunders Company.

UR - http://www.scopus.com/inward/record.url?scp=0034235062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034235062&partnerID=8YFLogxK

U2 - 10.1053/meta.2000.6750

DO - 10.1053/meta.2000.6750

M3 - Article

C2 - 10909994

AN - SCOPUS:0034235062

VL - 49

SP - 853

EP - 857

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

IS - 7

ER -