Streptococcus thermophilus ST28 ameliorates colitis in mice partially by suppression of inflammatory Th17 cells

Tasuku Ogita, Megumi Nakashima, Hidetoshi Morita, Yasuo Saito, Takuya Suzuki, Soichi Tanabe

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effects of Streptococcus thermophilus ST28 on cytokine production by murine splenocytes stimulated with transforming growth factor-β plus interleukin- (IL-) 6 were evaluated. The addition of ST28 significantly repressed IL-17 production compared to ATCC 19258 (type strain). ST28 also decreased the number of Th17 cells in the stimulated splenocytes. The anti-inflammatory effects of ST28 administration were evaluated in mice with colitis induced by dextran sodium sulphate (DSS). Oral treatment of mice with ST28 ameliorated the intestinal lesions by DSS. Upon DSS treatment, IL-17 production in lamina propria lymphocytes (LPLs) was induced, but ST28 significantly decreased its production. ST28 also decreased the percentage of Th17 cells in LPL from DSS-induced colitis. The present results imply that ST28 suppresses the Th17 response in inflamed intestines and would be useful in the treatment of Th17-mediated diseases, such as inflammatory bowel disease.

Original languageEnglish
Article number378417
JournalJournal of Biomedicine and Biotechnology
Volume2011
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Streptococcus thermophilus
Th17 Cells
Dextran Sulfate
Colitis
Lymphocytes
Interleukin-17
Mucous Membrane
Transforming Growth Factors
Inflammatory Bowel Diseases
Intestines
Interleukin-6
Anti-Inflammatory Agents
Cytokines

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Genetics
  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Streptococcus thermophilus ST28 ameliorates colitis in mice partially by suppression of inflammatory Th17 cells. / Ogita, Tasuku; Nakashima, Megumi; Morita, Hidetoshi; Saito, Yasuo; Suzuki, Takuya; Tanabe, Soichi.

In: Journal of Biomedicine and Biotechnology, Vol. 2011, 378417, 2011.

Research output: Contribution to journalArticle

@article{3f9d07f590be448bbd2214f33e47d4e2,
title = "Streptococcus thermophilus ST28 ameliorates colitis in mice partially by suppression of inflammatory Th17 cells",
abstract = "The effects of Streptococcus thermophilus ST28 on cytokine production by murine splenocytes stimulated with transforming growth factor-β plus interleukin- (IL-) 6 were evaluated. The addition of ST28 significantly repressed IL-17 production compared to ATCC 19258 (type strain). ST28 also decreased the number of Th17 cells in the stimulated splenocytes. The anti-inflammatory effects of ST28 administration were evaluated in mice with colitis induced by dextran sodium sulphate (DSS). Oral treatment of mice with ST28 ameliorated the intestinal lesions by DSS. Upon DSS treatment, IL-17 production in lamina propria lymphocytes (LPLs) was induced, but ST28 significantly decreased its production. ST28 also decreased the percentage of Th17 cells in LPL from DSS-induced colitis. The present results imply that ST28 suppresses the Th17 response in inflamed intestines and would be useful in the treatment of Th17-mediated diseases, such as inflammatory bowel disease.",
author = "Tasuku Ogita and Megumi Nakashima and Hidetoshi Morita and Yasuo Saito and Takuya Suzuki and Soichi Tanabe",
year = "2011",
doi = "10.1155/2011/378417",
language = "English",
volume = "2011",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Streptococcus thermophilus ST28 ameliorates colitis in mice partially by suppression of inflammatory Th17 cells

AU - Ogita, Tasuku

AU - Nakashima, Megumi

AU - Morita, Hidetoshi

AU - Saito, Yasuo

AU - Suzuki, Takuya

AU - Tanabe, Soichi

PY - 2011

Y1 - 2011

N2 - The effects of Streptococcus thermophilus ST28 on cytokine production by murine splenocytes stimulated with transforming growth factor-β plus interleukin- (IL-) 6 were evaluated. The addition of ST28 significantly repressed IL-17 production compared to ATCC 19258 (type strain). ST28 also decreased the number of Th17 cells in the stimulated splenocytes. The anti-inflammatory effects of ST28 administration were evaluated in mice with colitis induced by dextran sodium sulphate (DSS). Oral treatment of mice with ST28 ameliorated the intestinal lesions by DSS. Upon DSS treatment, IL-17 production in lamina propria lymphocytes (LPLs) was induced, but ST28 significantly decreased its production. ST28 also decreased the percentage of Th17 cells in LPL from DSS-induced colitis. The present results imply that ST28 suppresses the Th17 response in inflamed intestines and would be useful in the treatment of Th17-mediated diseases, such as inflammatory bowel disease.

AB - The effects of Streptococcus thermophilus ST28 on cytokine production by murine splenocytes stimulated with transforming growth factor-β plus interleukin- (IL-) 6 were evaluated. The addition of ST28 significantly repressed IL-17 production compared to ATCC 19258 (type strain). ST28 also decreased the number of Th17 cells in the stimulated splenocytes. The anti-inflammatory effects of ST28 administration were evaluated in mice with colitis induced by dextran sodium sulphate (DSS). Oral treatment of mice with ST28 ameliorated the intestinal lesions by DSS. Upon DSS treatment, IL-17 production in lamina propria lymphocytes (LPLs) was induced, but ST28 significantly decreased its production. ST28 also decreased the percentage of Th17 cells in LPL from DSS-induced colitis. The present results imply that ST28 suppresses the Th17 response in inflamed intestines and would be useful in the treatment of Th17-mediated diseases, such as inflammatory bowel disease.

UR - http://www.scopus.com/inward/record.url?scp=84855165217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855165217&partnerID=8YFLogxK

U2 - 10.1155/2011/378417

DO - 10.1155/2011/378417

M3 - Article

C2 - 22013382

AN - SCOPUS:84855165217

VL - 2011

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 378417

ER -