Stimulation of subthalamic nucleus for parkinsons disease

Takashi Agari, Isao Date

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


Subthalamic stimulation (STN-DBS) is an established treatment for the patients with advanced Parkinson’s disease (PD). It is considered a surgical treatment alternative for patients with intractable tremor or for those patients who are affected by long-term complications of levodopa therapy such as motor fluctuations and severe dyskinesias. The response to levodopa is a good prognostic factor for good therapeutic effect of STN-DBS. STN-DBS improves the off-period motor symptom and dyskinesias and allows to reduce the levodopa dose, to shorten the off-period and to improve activities of daily livings and quality of life of PD patients. Treatment timing of STN-DBS may be better to start from a relatively early stage of motor fluctuation to emerge to keep the QOL of patients with good long-term conditions. It is said that there is a possibility of causing a decline in cognition after STN-DBS. By performing the surgery with high accuracy, it may be possible to minimize complications of STN-DBS.

Original languageEnglish
Title of host publicationDeep Brain Stimulation for Neurological Disorders
Subtitle of host publicationTheoretical Background and Clinical Application
PublisherSpringer International Publishing
Number of pages14
ISBN (Electronic)9783319084763
ISBN (Print)9783319084756
Publication statusPublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)


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