Stimulation of subthalamic nucleus for parkinsons disease

Takashi Agari, Isao Date

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Subthalamic stimulation (STN-DBS) is an established treatment for the patients with advanced Parkinson’s disease (PD). It is considered a surgical treatment alternative for patients with intractable tremor or for those patients who are affected by long-term complications of levodopa therapy such as motor fluctuations and severe dyskinesias. The response to levodopa is a good prognostic factor for good therapeutic effect of STN-DBS. STN-DBS improves the off-period motor symptom and dyskinesias and allows to reduce the levodopa dose, to shorten the off-period and to improve activities of daily livings and quality of life of PD patients. Treatment timing of STN-DBS may be better to start from a relatively early stage of motor fluctuation to emerge to keep the QOL of patients with good long-term conditions. It is said that there is a possibility of causing a decline in cognition after STN-DBS. By performing the surgery with high accuracy, it may be possible to minimize complications of STN-DBS.

Original languageEnglish
Title of host publicationDeep Brain Stimulation for Neurological Disorders: Theoretical Background and Clinical Application
PublisherSpringer International Publishing
Pages73-86
Number of pages14
ISBN (Print)9783319084763, 9783319084756
DOIs
Publication statusPublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Agari, T., & Date, I. (2015). Stimulation of subthalamic nucleus for parkinsons disease. In Deep Brain Stimulation for Neurological Disorders: Theoretical Background and Clinical Application (pp. 73-86). Springer International Publishing. https://doi.org/10.1007/978-3-319-08476-3-7