Stimulation of monocyte iodination and IL-1 production by tannins and related compounds

H. Sakagami, K. Asano, S. I. Tanuma, T. Hatano, T. Yoshida, T. Okuda

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Various tannins and related compounds were compared for their ability to stimulate the iodination (incorporation of radioactive iodine into an acid-insoluble fraction) of human peripheral blood monocytes. The stimulating activity of most of the monomeric and dimeric hydrolyzable tannins was generally higher than that of the trimeric and tetrameric compounds. Compounds that had dehydrohexahydroxydiphenoyl or chebuloyl groups had considerably less activity than those that had other functional groups (hexahydroxydiphenoyl, valoneoyl, dehydrodigalloyl, isodehydrodigalloyl, lactonized valoneoyl, hellinoyl, euphorbinoyl, dehydroeuphorbinoyl or woodfordinoyl group). The methylated derivative, nonacosa-O-methylcoriariin A, was essentially inactive, suggesting the requirement of a phenolic hydroxyl group. Three condensed tannins ((-)-epicatechin 3-O-gallate (ECG)-dimer, ECG-trimer and ECG-tetramer) significantly stimulated both monocytc iodination and their interleukin-1-like factor production. The results suggest the dependence of stimulation of monocyte iodination by tannins and related polyphenols on molecular weight.

Original languageEnglish
Pages (from-to)377-387
Number of pages11
JournalAnticancer research
Issue number2
Publication statusPublished - Jan 1 1992
Externally publishedYes


  • IL-1
  • Iodination
  • Monocyte
  • Structure
  • Tannin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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