Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers

Masaki Sone, Mikio Hoshino, Emiko Suzuki, Shinya Kuroda, Kozo Kaibuchi, Hideki Nakagoshi, Kaoru Saigo, Yo Ichi Nabeshima, Chihiro Hama

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The morphology of axon terminals changes with differentiation into mature synapses. A molecule that might regulate this process was identified by a screen of Drosophila mutants for abnormal motor activities. The still life (sif) gene encodes a protein homologous to guanine nucleotide exchange factors, which convert Rho-like guanosine triphosphatases (GTPases) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The SIF proteins are found adjacent to the plasma membrane of synaptic terminals. Expression of a truncated SIF protein resulted in defects in neuronal morphology and induced membrane ruffling with altered actin localization in human KB cells. Thus, SIF proteins may regulate synaptic differentiation through the organization of the actin cytoskeleton by activating Rho-like GTPases.

Original languageEnglish
Pages (from-to)543-547
Number of pages5
JournalScience
Volume275
Issue number5299
DOIs
Publication statusPublished - Jan 24 1997
Externally publishedYes

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Presynaptic Terminals
Guanosine Triphosphate
Drosophila
Guanosine
Proteins
Guanine Nucleotide Exchange Factors
KB Cells
Diphosphates
Actin Cytoskeleton
Synapses
Actins
Motor Activity
Cell Membrane
Membranes
Genes

ASJC Scopus subject areas

  • General

Cite this

Sone, M., Hoshino, M., Suzuki, E., Kuroda, S., Kaibuchi, K., Nakagoshi, H., ... Hama, C. (1997). Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers. Science, 275(5299), 543-547. https://doi.org/10.1126/science.275.5299.543

Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers. / Sone, Masaki; Hoshino, Mikio; Suzuki, Emiko; Kuroda, Shinya; Kaibuchi, Kozo; Nakagoshi, Hideki; Saigo, Kaoru; Nabeshima, Yo Ichi; Hama, Chihiro.

In: Science, Vol. 275, No. 5299, 24.01.1997, p. 543-547.

Research output: Contribution to journalArticle

Sone, M, Hoshino, M, Suzuki, E, Kuroda, S, Kaibuchi, K, Nakagoshi, H, Saigo, K, Nabeshima, YI & Hama, C 1997, 'Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers', Science, vol. 275, no. 5299, pp. 543-547. https://doi.org/10.1126/science.275.5299.543
Sone, Masaki ; Hoshino, Mikio ; Suzuki, Emiko ; Kuroda, Shinya ; Kaibuchi, Kozo ; Nakagoshi, Hideki ; Saigo, Kaoru ; Nabeshima, Yo Ichi ; Hama, Chihiro. / Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers. In: Science. 1997 ; Vol. 275, No. 5299. pp. 543-547.
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