Stereospecific reduction of phosphine oxides to phosphines by the use of a methylation reagent and lithium aluminum hydride

Tsuneo Imamoto, Shin Ichi Kikuchi, Tomoya Miura, Yoshiyuki Wada

Research output: Contribution to journalArticlepeer-review

146 Citations (Scopus)

Abstract

(equation presented) Various phosphine oxides are efficiently reduced by the use of a methylation reagent and lithium aluminum hydride. Optically active P-chirogenic phosphine oxides are also reduced with inversion of configuration at phosphorus atom by treatment with methyl triflate, followed by reaction with LiAlH4.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalOrganic Letters
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 11 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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