Abstract
Symbiodinolide is a polyol macrolide isolated from the marine dinoflagellate Symbiodinium sp. in 2007. The C14-C24 fragment of symbiodinolide possessing the 17R/18R/21R absolute configuration, which was obtained as one of the degraded products of symbiodinolide, was synthesized stereoselectively from cis-2-butene-1,4-diol. The detailed comparison of the synthetic product with the degraded product in the spectroscopic data confirmed that the stereostructure of the C14-C24 fragment was 17R, 18R, and 21R.
Original language | English |
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Pages (from-to) | 2603-2605 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 51 |
Issue number | 19 |
DOIs | |
Publication status | Published - May 12 2010 |
Keywords
- Polyol macrolide
- Stereoselective synthesis
- Structural confirmation
- Symbiodinolide
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry