Stereoselective synthesis of (E)-ArCFCFR and (E)-ArCHCFR from ArCH(OH)CFBr2

Manabu Kuroboshi, Nobuko Yamada, Yoko Takebe, Tamejiro Hiyama

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

(E)-vic-Difluoro olefin, RCFCFBr, was synthesized by dehydrobromination of RCFHCFBr2 using lithium 2,2,6,6-tetramethylpiperidide. (E)-Fluoro olefin, RCHCFBr, was obtained by treatment of RCH(OAc)CFBr2 with EtMgBr and HN(i-Pr)2.

Original languageEnglish
Pages (from-to)6271-6274
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number35
DOIs
Publication statusPublished - Aug 28 1995
Externally publishedYes

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Alkenes
lithium 2,2,6,6-tetramethylpiperidide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Stereoselective synthesis of (E)-ArCFCFR and (E)-ArCHCFR from ArCH(OH)CFBr2. / Kuroboshi, Manabu; Yamada, Nobuko; Takebe, Yoko; Hiyama, Tamejiro.

In: Tetrahedron Letters, Vol. 36, No. 35, 28.08.1995, p. 6271-6274.

Research output: Contribution to journalArticle

Kuroboshi, Manabu ; Yamada, Nobuko ; Takebe, Yoko ; Hiyama, Tamejiro. / Stereoselective synthesis of (E)-ArCFCFR and (E)-ArCHCFR from ArCH(OH)CFBr2. In: Tetrahedron Letters. 1995 ; Vol. 36, No. 35. pp. 6271-6274.
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