Stereocontrolled synthesis of the macrolactone core of neopeltolide

Andreas Meissner, Nobuhiro Tanaka, Hiroyoshi Takamura, Isao Kadota

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A stereoselective synthesis of the macrolactone core of neopeltolide is described. The tetrahydropyran moiety was constructed via the intramolecular allylation of an α-acetoxy ether. A late-stage macrolactonization provided a known synthetic intermediate of neopeltolide.

Original languageEnglish
JournalTetrahedron Letters
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Allylation
Ether
neopeltolide

Keywords

  • Allylation
  • Convergent synthesis
  • Macrolide
  • Neopeltolide
  • Reductive acetylation

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Stereocontrolled synthesis of the macrolactone core of neopeltolide. / Meissner, Andreas; Tanaka, Nobuhiro; Takamura, Hiroyoshi; Kadota, Isao.

In: Tetrahedron Letters, 01.01.2019.

Research output: Contribution to journalArticle

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