Stereochemistry of enacyloxins 2. Structure elucidation of decarbamoyl enacyloxin IIa and IVa, new members of enacyloxin antibiotics from Frateuria sp. W-315

Toshihiko Watanabe, Hiromasa Kiyota, Ryo Takeuchi, Keijiro Enari, Takayuki Oritani

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Two new members of enacyloxins (ENXs) were isolated from the culture extract of Frateuria sp. W-315. Spectrometric analyses revealed their structures as decarbamoyl enacyloxin IVa and IIa, the latter preferentially existed in the hemiacetal form. Formation of these compounds were catalyzed by enzymes produced by the fungus. From the coupling constant values of the hemiacetal part of dec ENX IIa, the (17′R*, 18′S*, 19′R*) relative configuration of ENXs was also elucidated.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalHeterocyclic Communications
Volume7
Issue number4
DOIs
Publication statusPublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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