Stem cell therapy for cerebral ischemia: From basic science to clinical applications

Koji Abe, Toru Yamashita, Shunya Takizawa, Satoshi Kuroda, Hiroyuki Kinouchi, Nobutaka Kawahara

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Recent stem cell technology provides a strong therapeutic potential not only for acute ischemic stroke but also for chronic progressive neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis with neuroregenerative neural cell replenishment and replacement. In addition to resident neural stem cell activation in the brain by neurotrophic factors, bone marrow stem cells (BMSCs) can be mobilized by granulocyte-colony stimulating factor for homing into the brain for both neurorepair and neuroregeneration in acute stroke and neurodegenerative diseases in both basic science and clinical settings. Exogenous stem cell transplantation is also emerging into a clinical scene from bench side experiments. Early clinical trials of intravenous transplantation of autologous BMSCs are showing safe and effective results in stroke patients. Further basic sciences of stem cell therapy on a neurovascular unit and neuroregeneration, and further clinical advancements on scaffold technology for supporting stem cells and stem cell tracking technology such as magnetic resonance imaging, single photon emission tomography or optical imaging with near-infrared could allow stem cell therapy to be applied in daily clinical applications in the near future.

Original languageEnglish
Pages (from-to)1317-1331
Number of pages15
JournalJournal of Cerebral Blood Flow and Metabolism
Volume32
Issue number7
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Cell- and Tissue-Based Therapy
Brain Ischemia
Stem Cells
Stroke
Technology
Bone Marrow Cells
Neurodegenerative Diseases
Cell Tracking
Neural Stem Cells
Autologous Transplantation
Optical Imaging
Nerve Growth Factors
Amyotrophic Lateral Sclerosis
Brain
Stem Cell Transplantation
Acute Disease
Granulocyte Colony-Stimulating Factor
Photons
Parkinson Disease
Alzheimer Disease

Keywords

  • Cerebral ischemia
  • neuroregeneration
  • neurorepair
  • stem cell therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Stem cell therapy for cerebral ischemia : From basic science to clinical applications. / Abe, Koji; Yamashita, Toru; Takizawa, Shunya; Kuroda, Satoshi; Kinouchi, Hiroyuki; Kawahara, Nobutaka.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 32, No. 7, 07.2012, p. 1317-1331.

Research output: Contribution to journalArticle

Abe, Koji ; Yamashita, Toru ; Takizawa, Shunya ; Kuroda, Satoshi ; Kinouchi, Hiroyuki ; Kawahara, Nobutaka. / Stem cell therapy for cerebral ischemia : From basic science to clinical applications. In: Journal of Cerebral Blood Flow and Metabolism. 2012 ; Vol. 32, No. 7. pp. 1317-1331.
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