Stem cell therapies in patients with single ventricle physiology

Suguru Tarui, Shunji Sano, Hidemasa Oh

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Single ventricle physiology, especially hypoplastic left heart syndrome, is one of the most high-risk lesions in children with congenital heart disease, and the ensuing heart failure remains as a major problem related to adverse outcomes in these patients. The field of stem cell therapy for heart failure has shown striking advances during the past 10 years, and many clinical trials using stem cell technologies have been conducted in adults, which suggest that stem cell therapy is associated with long-term improvement in cardiac function. Cardiac progenitor cells have recently been discovered, and their strong regenerative ability has been demonstrated in several studies. Although no large clinical trials have been performed in the field of congenital heart disease, recent investigations indicate that stem cell therapy may hold great potential to treat children with cardiac defects.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalMethodist DeBakey cardiovascular journal
Volume10
Issue number2
Publication statusPublished - Apr 1 2014

Keywords

  • cardiac progenitors
  • cell therapy
  • congenital heart disease
  • hypoplastic left heart syndrome
  • single ventricle physiology

ASJC Scopus subject areas

  • Medicine(all)

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