Steering target selectivity and potency by fragment-based de novo drug design

Tiago Rodrigues, Takayuki Kudoh, Filip Roudnicky, Yi Fan Lim, Yen Chu Lin, Christian P. Koch, Masaharu Seno, Michael Detmar, Gisbert Schneider

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Kinase inhibitors: Ligand-based de novo design is validated as a viable technology for rapidly generating innovative compounds possessing the desired biochemical profile. The study discloses the discovery of the most selective vascular endothelial growth factor receptor-2 (VEGFR-2) kinase inhibitor (right in scheme) known to date as prime lead for antiangiogenic drug development.

Original languageEnglish
Pages (from-to)10006-10009
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number38
DOIs
Publication statusPublished - Sep 16 2013

Keywords

  • VEGFR
  • drug design
  • drug discovery
  • fragment-based design
  • kinase inhibitors

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint

Dive into the research topics of 'Steering target selectivity and potency by fragment-based de novo drug design'. Together they form a unique fingerprint.

Cite this