Abstract
The shape of mixed dipalmitoylphosphatidylcholine (DPPC)/stearylamine (SA) liposomes prepared by the Bangham method was examined using freeze-fracture electron microscopy. The shape of the mixed DPPC/SA liposomes (XSA = 0.05) was not that of multilamellar vesicles (MLVs) but large unilamellar vesicles (LUVs) with a diameter of approximately 1.0 μm. These facts overthrow the preconceived idea that the shape of the DPPC/SA liposomes prepared by the Bangham method is that of MLVs. The trapping efficiency of the mixed DPPC/SA liposomes (XSA = 0.05) was ten times greater than that of the DPPC liposomes, since the DPPC liposomes were MLVs. The data of the DSC peak for the DPPC/SA liposomes also indicated that the shape of the DPPC/SA liposomes is that of LUVs. We emphasize that the shape of the DPPC liposomes changes from that of MLVs to LUVs by the mixing of a small amount of SA into the DPPC liposomes.
Original language | English |
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Pages (from-to) | 251-254 |
Number of pages | 4 |
Journal | Journal of Oleo Science |
Volume | 54 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2005 |
Externally published | Yes |
Keywords
- freeze-fracture electron microscopy
- large unilamellar vesicle
- mixed liposome
- stearylamine
- trapping efficiency
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)