TY - JOUR
T1 - Standard protocol devised by the Japanese Pediatric Impedance Working Group for combined multichannel intraluminal impedance-pH measurements in children
AU - Japanese Pediatric Impedance Working Group (Japanese-PIG)
AU - Fukahori, Suguru
AU - Kawahara, Hisayoshi
AU - Oyama, Takanori
AU - Saito, Takeshi
AU - Shimono, Ryuichi
AU - Tanaka, Aya
AU - Noda, Takuo
AU - Hatori, Reiko
AU - Fujino, Junko
AU - Yagi, Minoru
N1 - Funding Information:
We thank Professor. Daniel Sifrim and Dr. Taher Omari for their valuable expert insights, which helped us to establish the present MII-pH protocol. We also thank the Japanese Pediatric Gastrointestinal Motility Society for their continued support.
Publisher Copyright:
© 2019, The Author(s).
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Multichannel intraluminal impedance-pH measurements (MII-pH) are useful for evaluating acid and non-acid gastroesophageal reflux (GER). However, the use of MIH-pH is not yet established in Japan. The Japanese Pediatric Impedance Working Group (Japanese-PIG) convened to devise a standard protocol for MII-pH in Japanese children. The expert members of the Japanese-PIG collected data on pediatric MII-pH from the relevant literature in English, including the standard protocol of MII-pH presented by the European PIG, and the insights of international experts. The resultant consensus was included in the contents of the standard protocol of MII-pH. The standard protocol included standardization of the indication, methodology, and interpretation of MII-pH in Japanese children. The criteria for abnormal GER by MII-pH were defined using the Reflux Index and number of total reflux episodes independently in children aged < 1 year and those aged ≥ 1 year. Moreover, a significant relationship between GER and symptoms was identified using the symptom index and symptom association probability approach. We conclude that the current version of the protocol for MII-pH is tentative because it is not based on data from Japanese children. Further studies are needed to render this protocol clinically beneficial and expand its use in Japan.
AB - Multichannel intraluminal impedance-pH measurements (MII-pH) are useful for evaluating acid and non-acid gastroesophageal reflux (GER). However, the use of MIH-pH is not yet established in Japan. The Japanese Pediatric Impedance Working Group (Japanese-PIG) convened to devise a standard protocol for MII-pH in Japanese children. The expert members of the Japanese-PIG collected data on pediatric MII-pH from the relevant literature in English, including the standard protocol of MII-pH presented by the European PIG, and the insights of international experts. The resultant consensus was included in the contents of the standard protocol of MII-pH. The standard protocol included standardization of the indication, methodology, and interpretation of MII-pH in Japanese children. The criteria for abnormal GER by MII-pH were defined using the Reflux Index and number of total reflux episodes independently in children aged < 1 year and those aged ≥ 1 year. Moreover, a significant relationship between GER and symptoms was identified using the symptom index and symptom association probability approach. We conclude that the current version of the protocol for MII-pH is tentative because it is not based on data from Japanese children. Further studies are needed to render this protocol clinically beneficial and expand its use in Japan.
KW - Children
KW - Gastroesophageal reflux
KW - Multichannel intraluminal impedance-pH measurements
KW - Standard protocol
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U2 - 10.1007/s00595-019-01833-6
DO - 10.1007/s00595-019-01833-6
M3 - Review article
C2 - 31214780
AN - SCOPUS:85067677472
VL - 50
SP - 664
EP - 671
JO - Japanese Journal of Surgery
JF - Japanese Journal of Surgery
SN - 0941-1291
IS - 7
ER -