Stage of hepatocellular carcinoma is associated with periodontitis

Naofumi Tamaki, Akinobu Takaki, Takaaki Tomofuji, Yasumasa Endo, Kenta Kasuyama, Daisuke Ekuni, Tetsuya Yasunaka, Kazuhide Yamamoto, Manabu Morita

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aim Periodontitis induces overproduction of reactive oxygen species (ROS). This state increases circulating ROS levels and may affect hepatocellular carcinoma (HCC). The Japan Integrated Stage (JIS) score is a novel staging system for HCC. The objective of the present study was to compare JIS scores in HCC patients with and without periodontitis. Material and Methods We recruited 64 HCC patients comprising 31 chronic periodontitis subjects (HCC + P) and 33 periodontally healthy controls (HCC + H). Their JIS scores were recorded. Serum levels of reactive oxygen metabolites (ROM) from HCC + P, HCC + H and healthy age- and gender-matched subjects with healthy gingiva (control, n = 15) were also assessed for circulating ROS levels. Results The HCC + P and HCC + H groups had similar body mass index, habitual drinking and tobacco exposure data. The HCC + P group showed higher JIS scores than the HCC + H group (p = 0.027). Both the HCC + P and HCC + H groups had higher serum levels of ROM than controls (p <0.001), while serum levels of ROM in the HCC + P group were a further 25.8% higher than those in the HCC + H group (p <0.001). Conclusion HCC patients with periodontitis had higher JIS score and circulating ROS level than HCC patients without periodontitis.

Original languageEnglish
Pages (from-to)1015-1020
Number of pages6
JournalJournal of Clinical Periodontology
Volume38
Issue number11
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Periodontitis
Hepatocellular Carcinoma
Japan
Reactive Oxygen Species
Oxygen
Serum
Chronic Periodontitis
Gingiva

Keywords

  • anti-oxidant
  • carcinoma, hepatocellular
  • JIS score
  • oxidative stress
  • periodontitis

ASJC Scopus subject areas

  • Periodontics

Cite this

Stage of hepatocellular carcinoma is associated with periodontitis. / Tamaki, Naofumi; Takaki, Akinobu; Tomofuji, Takaaki; Endo, Yasumasa; Kasuyama, Kenta; Ekuni, Daisuke; Yasunaka, Tetsuya; Yamamoto, Kazuhide; Morita, Manabu.

In: Journal of Clinical Periodontology, Vol. 38, No. 11, 11.2011, p. 1015-1020.

Research output: Contribution to journalArticle

Tamaki, Naofumi ; Takaki, Akinobu ; Tomofuji, Takaaki ; Endo, Yasumasa ; Kasuyama, Kenta ; Ekuni, Daisuke ; Yasunaka, Tetsuya ; Yamamoto, Kazuhide ; Morita, Manabu. / Stage of hepatocellular carcinoma is associated with periodontitis. In: Journal of Clinical Periodontology. 2011 ; Vol. 38, No. 11. pp. 1015-1020.
@article{dafb80b3215b411b91a428cd13ed67af,
title = "Stage of hepatocellular carcinoma is associated with periodontitis",
abstract = "Aim Periodontitis induces overproduction of reactive oxygen species (ROS). This state increases circulating ROS levels and may affect hepatocellular carcinoma (HCC). The Japan Integrated Stage (JIS) score is a novel staging system for HCC. The objective of the present study was to compare JIS scores in HCC patients with and without periodontitis. Material and Methods We recruited 64 HCC patients comprising 31 chronic periodontitis subjects (HCC + P) and 33 periodontally healthy controls (HCC + H). Their JIS scores were recorded. Serum levels of reactive oxygen metabolites (ROM) from HCC + P, HCC + H and healthy age- and gender-matched subjects with healthy gingiva (control, n = 15) were also assessed for circulating ROS levels. Results The HCC + P and HCC + H groups had similar body mass index, habitual drinking and tobacco exposure data. The HCC + P group showed higher JIS scores than the HCC + H group (p = 0.027). Both the HCC + P and HCC + H groups had higher serum levels of ROM than controls (p <0.001), while serum levels of ROM in the HCC + P group were a further 25.8{\%} higher than those in the HCC + H group (p <0.001). Conclusion HCC patients with periodontitis had higher JIS score and circulating ROS level than HCC patients without periodontitis.",
keywords = "anti-oxidant, carcinoma, hepatocellular, JIS score, oxidative stress, periodontitis",
author = "Naofumi Tamaki and Akinobu Takaki and Takaaki Tomofuji and Yasumasa Endo and Kenta Kasuyama and Daisuke Ekuni and Tetsuya Yasunaka and Kazuhide Yamamoto and Manabu Morita",
year = "2011",
month = "11",
doi = "10.1111/j.1600-051X.2011.01777.x",
language = "English",
volume = "38",
pages = "1015--1020",
journal = "Journal of Clinical Periodontology",
issn = "0303-6979",
publisher = "Blackwell Munksgaard",
number = "11",

}

TY - JOUR

T1 - Stage of hepatocellular carcinoma is associated with periodontitis

AU - Tamaki, Naofumi

AU - Takaki, Akinobu

AU - Tomofuji, Takaaki

AU - Endo, Yasumasa

AU - Kasuyama, Kenta

AU - Ekuni, Daisuke

AU - Yasunaka, Tetsuya

AU - Yamamoto, Kazuhide

AU - Morita, Manabu

PY - 2011/11

Y1 - 2011/11

N2 - Aim Periodontitis induces overproduction of reactive oxygen species (ROS). This state increases circulating ROS levels and may affect hepatocellular carcinoma (HCC). The Japan Integrated Stage (JIS) score is a novel staging system for HCC. The objective of the present study was to compare JIS scores in HCC patients with and without periodontitis. Material and Methods We recruited 64 HCC patients comprising 31 chronic periodontitis subjects (HCC + P) and 33 periodontally healthy controls (HCC + H). Their JIS scores were recorded. Serum levels of reactive oxygen metabolites (ROM) from HCC + P, HCC + H and healthy age- and gender-matched subjects with healthy gingiva (control, n = 15) were also assessed for circulating ROS levels. Results The HCC + P and HCC + H groups had similar body mass index, habitual drinking and tobacco exposure data. The HCC + P group showed higher JIS scores than the HCC + H group (p = 0.027). Both the HCC + P and HCC + H groups had higher serum levels of ROM than controls (p <0.001), while serum levels of ROM in the HCC + P group were a further 25.8% higher than those in the HCC + H group (p <0.001). Conclusion HCC patients with periodontitis had higher JIS score and circulating ROS level than HCC patients without periodontitis.

AB - Aim Periodontitis induces overproduction of reactive oxygen species (ROS). This state increases circulating ROS levels and may affect hepatocellular carcinoma (HCC). The Japan Integrated Stage (JIS) score is a novel staging system for HCC. The objective of the present study was to compare JIS scores in HCC patients with and without periodontitis. Material and Methods We recruited 64 HCC patients comprising 31 chronic periodontitis subjects (HCC + P) and 33 periodontally healthy controls (HCC + H). Their JIS scores were recorded. Serum levels of reactive oxygen metabolites (ROM) from HCC + P, HCC + H and healthy age- and gender-matched subjects with healthy gingiva (control, n = 15) were also assessed for circulating ROS levels. Results The HCC + P and HCC + H groups had similar body mass index, habitual drinking and tobacco exposure data. The HCC + P group showed higher JIS scores than the HCC + H group (p = 0.027). Both the HCC + P and HCC + H groups had higher serum levels of ROM than controls (p <0.001), while serum levels of ROM in the HCC + P group were a further 25.8% higher than those in the HCC + H group (p <0.001). Conclusion HCC patients with periodontitis had higher JIS score and circulating ROS level than HCC patients without periodontitis.

KW - anti-oxidant

KW - carcinoma, hepatocellular

KW - JIS score

KW - oxidative stress

KW - periodontitis

UR - http://www.scopus.com/inward/record.url?scp=80054057879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054057879&partnerID=8YFLogxK

U2 - 10.1111/j.1600-051X.2011.01777.x

DO - 10.1111/j.1600-051X.2011.01777.x

M3 - Article

VL - 38

SP - 1015

EP - 1020

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

SN - 0303-6979

IS - 11

ER -