Stability of meropenem and effect of 1β-methyl substitution on its stability in the presence of renal dehydropeptidase I

M. Fukasawa, Y. Sumita, E. T. Harabe, T. Tanio, H. Nouda, T. Kohzuki, T. Okuda, H. Matsumura, M. Sunagawa

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Abstract

The stability of meropenem in the presence of renal dehydropeptidase I (DHP-I) varied extremely with the animal source of the enzyme. Meropenem, compared with imipenem, was rather easily hydrolyzed by DHP-Is from mice, rabbits, and monkeys, while it showed a higher resistance to guinea pig and beagle dog DHP-Is. In addition, meropenem was four times more resistant than imipenem to human DHP-I. The 1β-methyl substituent on carbapenems, i.e., meropenem and 1β-methyl imipenem, made them considerably more resistant to mouse and swine DHP-Is than the 1-unsubstituted derivatives are.

Original languageEnglish
Pages (from-to)1577-1579
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume36
Issue number7
DOIs
Publication statusPublished - Jan 1 1992

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Fukasawa, M., Sumita, Y., Harabe, E. T., Tanio, T., Nouda, H., Kohzuki, T., Okuda, T., Matsumura, H., & Sunagawa, M. (1992). Stability of meropenem and effect of 1β-methyl substitution on its stability in the presence of renal dehydropeptidase I. Antimicrobial Agents and Chemotherapy, 36(7), 1577-1579. https://doi.org/10.1128/AAC.36.7.1577