Stability of meropenem and effect of 1β-methyl substitution on its stability in the presence of renal dehydropeptidase I

M. Fukasawa, Yoshihiro Sumita, E. T. Harabe, T. Tanio, H. Nouda, T. Kohzuki, T. Okuda, H. Matsumura, M. Sunagawa

Research output: Contribution to journalComment/debate

113 Citations (Scopus)

Abstract

The stability of meropenem in the presence of renal dehydropeptidase I (DHP-I) varied extremely with the animal source of the enzyme. Meropenem, compared with imipenem, was rather easily hydrolyzed by DHP-Is from mice, rabbits, and monkeys, while it showed a higher resistance to guinea pig and beagle dog DHP-Is. In addition, meropenem was four times more resistant than imipenem to human DHP-I. The 1β-methyl substituent on carbapenems, i.e., meropenem and 1β-methyl imipenem, made them considerably more resistant to mouse and swine DHP-Is than the 1-unsubstituted derivatives are.

Original languageEnglish
Pages (from-to)1577-1579
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume36
Issue number7
DOIs
Publication statusPublished - Jan 1 1992
Externally publishedYes

Fingerprint

meropenem
dipeptidase 1
Imipenem
Kidney
Carbapenems
Haplorhini
Guinea Pigs
Swine
Dogs
Rabbits
Enzymes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Stability of meropenem and effect of 1β-methyl substitution on its stability in the presence of renal dehydropeptidase I. / Fukasawa, M.; Sumita, Yoshihiro; Harabe, E. T.; Tanio, T.; Nouda, H.; Kohzuki, T.; Okuda, T.; Matsumura, H.; Sunagawa, M.

In: Antimicrobial Agents and Chemotherapy, Vol. 36, No. 7, 01.01.1992, p. 1577-1579.

Research output: Contribution to journalComment/debate

Fukasawa, M. ; Sumita, Yoshihiro ; Harabe, E. T. ; Tanio, T. ; Nouda, H. ; Kohzuki, T. ; Okuda, T. ; Matsumura, H. ; Sunagawa, M. / Stability of meropenem and effect of 1β-methyl substitution on its stability in the presence of renal dehydropeptidase I. In: Antimicrobial Agents and Chemotherapy. 1992 ; Vol. 36, No. 7. pp. 1577-1579.
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AU - Tanio, T.

AU - Nouda, H.

AU - Kohzuki, T.

AU - Okuda, T.

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AB - The stability of meropenem in the presence of renal dehydropeptidase I (DHP-I) varied extremely with the animal source of the enzyme. Meropenem, compared with imipenem, was rather easily hydrolyzed by DHP-Is from mice, rabbits, and monkeys, while it showed a higher resistance to guinea pig and beagle dog DHP-Is. In addition, meropenem was four times more resistant than imipenem to human DHP-I. The 1β-methyl substituent on carbapenems, i.e., meropenem and 1β-methyl imipenem, made them considerably more resistant to mouse and swine DHP-Is than the 1-unsubstituted derivatives are.

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