TY - JOUR
T1 - Stability of meropenem and effect of 1β-methyl substitution on its stability in the presence of renal dehydropeptidase I
AU - Fukasawa, M.
AU - Sumita, Y.
AU - Harabe, E. T.
AU - Tanio, T.
AU - Nouda, H.
AU - Kohzuki, T.
AU - Okuda, T.
AU - Matsumura, H.
AU - Sunagawa, M.
PY - 1992
Y1 - 1992
N2 - The stability of meropenem in the presence of renal dehydropeptidase I (DHP-I) varied extremely with the animal source of the enzyme. Meropenem, compared with imipenem, was rather easily hydrolyzed by DHP-Is from mice, rabbits, and monkeys, while it showed a higher resistance to guinea pig and beagle dog DHP-Is. In addition, meropenem was four times more resistant than imipenem to human DHP-I. The 1β-methyl substituent on carbapenems, i.e., meropenem and 1β-methyl imipenem, made them considerably more resistant to mouse and swine DHP-Is than the 1-unsubstituted derivatives are.
AB - The stability of meropenem in the presence of renal dehydropeptidase I (DHP-I) varied extremely with the animal source of the enzyme. Meropenem, compared with imipenem, was rather easily hydrolyzed by DHP-Is from mice, rabbits, and monkeys, while it showed a higher resistance to guinea pig and beagle dog DHP-Is. In addition, meropenem was four times more resistant than imipenem to human DHP-I. The 1β-methyl substituent on carbapenems, i.e., meropenem and 1β-methyl imipenem, made them considerably more resistant to mouse and swine DHP-Is than the 1-unsubstituted derivatives are.
UR - http://www.scopus.com/inward/record.url?scp=0026725416&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026725416&partnerID=8YFLogxK
U2 - 10.1128/AAC.36.7.1577
DO - 10.1128/AAC.36.7.1577
M3 - Comment/debate
C2 - 1510457
AN - SCOPUS:0026725416
SN - 0066-4804
VL - 36
SP - 1577
EP - 1579
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 7
ER -
