ヒスチジン銅注射液の安定性およびヒスタミン含有量の検討

Translated title of the contribution: Stability of Copper Histidinate Injection and Histamine Formation in Menkes Disease

Youichi Kawasaki, 徳永 紳, 松香 直行, 出石 通博, 横山 紀子, 川島 理恵子, 亀井 千晃, Toshiaki Sendou, 五味田 裕

Research output: Contribution to journalArticle

Abstract

Menkes disease is characterized by inhibition of the absorption and transport of dietary copper. The Okayama University Medical and Dental School uses L-histidine-copper to treat this disease and in the present study, we examined the stability of the copper histidinate injection solution used for this purpose. High-performance liquid chromatography (HPLC) performed on day 56 following injection revealed that histidine levels had dropped to 90.4%, a non-significant decrease and histamine levels were unchanged. Moreover, atomic absorption spectrophotometry revealed that copper concentrations were not significantly decreased (89.7%) between days 0 and 56. Through visual observation, we noted a gradual increase in floats from day 42 to day 56, leading us to suggest that the use of copper histidinate be limited to 1 month. The above results should alleviate any concern about histamine-associated adverse effects.
Translated title of the contributionStability of Copper Histidinate Injection and Histamine Formation in Menkes Disease
Original languageJapanese
Pages (from-to)1133-1137
Number of pages5
Journal医療薬学
Volume32
Issue number11
DOIs
Publication statusPublished - Nov 10 2006

Keywords

  • copper histidinate
  • Menkes disease
  • histamine
  • high performance liquid chromatography
  • atomic absorption spectrophotometer
  • stability

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  • Cite this

    Kawasaki, Y., 徳永紳, 松香直行, 出石通博, 横山紀子, 川島理恵子, 亀井千晃, Sendou, T., & 五味田裕 (2006). ヒスチジン銅注射液の安定性およびヒスタミン含有量の検討. 医療薬学, 32(11), 1133-1137. https://doi.org/10.5649/jjphcs.32.1133