Viral long distant transport is an essential step for systemic infection. Because the process involves different types of highly differentiated vascular-associated cells, the virus systemic movement is regulated differentially at each tissue interface. In this chapter, we review current knowledge about viral systemic transport process in non-Arabidopsis hosts. We especially focus on viral and host factors participating in viral systemic transport. We also briefly overview the effect of RNA silencing, the host innate immunity, on viral systemic movement.