Spontaneous regression of transverse colon cancer with high-frequency microsatellite instability: A case report and literature review

Nozomi Karakuchi, Manabu Shimomura, Kazuhiro Toyota, Takao Hinoi, Hideki Yamamoto, Seiji Sadamoto, Koichi Mandai, Hiroyuki Egi, Hideki Ohdan, Tadateru Takahashi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Background: Spontaneous regression (SR) of colorectal cancer (CRC) is extremely rare, and only few cases have been reported. Although it is not yet clarified, a plausible mechanism for SR of CRC is an immunological event. Case presentation: In this report, we present the case of SR of primary CRC in a 78-year-old man. Preoperative colonoscopy was performed, and a type 2 tumor measuring 30 mm in diameter in the transverse colon was detected. The biopsy revealed a poorly differentiated adenocarcinoma. Colectomy was performed 2 months after initial colonoscopy. During the surgery, only a 10-mm ulcer harboring a polypoid lesion measuring 8.5 mm was detected in the resected tissue; no other masses or carcinoma cells were seen on histological examination. Afterwards, the biopsy specimens were reanalyzed, and immunohistological analysis verified this as adenocarcinoma with stroma-infiltrating lymphocytes. Further analysis revealed a loss of two mismatch repair proteins, suggesting sporadic high-frequency microsatellite instability (MSI-H). Conclusion: According to previous literature, a common site of SR in CRC is the proximal colon, which is a feature of MSI-H CRC. However, our report showed a rare case of SR of CRC, which was in the transverse colon, with MSI-H present. This report indicates a relationship between immunological features of MSI-H and the occurrence of SR of CRC. A better understanding of this phenomenon and the mechanisms involved will have significant preventive and therapeutic implications for CRC, including anti-PD-1 immune checkpoint inhibitor therapy.

Original languageEnglish
Article number19
JournalWorld Journal of Surgical Oncology
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 15 2019
Externally publishedYes

Fingerprint

Transverse Colon
Microsatellite Instability
Colonic Neoplasms
Colorectal Neoplasms
Colonoscopy
Adenocarcinoma
Biopsy
DNA Mismatch Repair
Colectomy
Ulcer
Colon
Lymphocytes
Carcinoma
N-methylsuccinimide
Therapeutics

Keywords

  • Colorectal cancer
  • Microsatellite instability
  • Spontaneous regression

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Spontaneous regression of transverse colon cancer with high-frequency microsatellite instability : A case report and literature review. / Karakuchi, Nozomi; Shimomura, Manabu; Toyota, Kazuhiro; Hinoi, Takao; Yamamoto, Hideki; Sadamoto, Seiji; Mandai, Koichi; Egi, Hiroyuki; Ohdan, Hideki; Takahashi, Tadateru.

In: World Journal of Surgical Oncology, Vol. 17, No. 1, 19, 15.01.2019.

Research output: Contribution to journalReview article

Karakuchi, Nozomi ; Shimomura, Manabu ; Toyota, Kazuhiro ; Hinoi, Takao ; Yamamoto, Hideki ; Sadamoto, Seiji ; Mandai, Koichi ; Egi, Hiroyuki ; Ohdan, Hideki ; Takahashi, Tadateru. / Spontaneous regression of transverse colon cancer with high-frequency microsatellite instability : A case report and literature review. In: World Journal of Surgical Oncology. 2019 ; Vol. 17, No. 1.
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