Spontaneous regression of primary lung cancer arising from an emphysematous bulla

Masashi Furukawa, Takahiro Oto, Masaomi Yamane, Shinichi Toyooka, Katsuyuki Kiura, Shinichiro Miyoshi

Research output: Contribution to journalArticle

12 Citations (Scopus)


Bullous emphysema is an important risk factor for lung cancer. Here, we report the case of a 56-year-old man who underwent surgical treatment for primary lung cancer arising from the wall of a bulla. Chest computed tomography (CT) had revealed a nodule arising from the bulla wall. This nodule showed positive uptake of 18fluorodeoxyglucose (FDG) during positron emission tomography (PET)-CT. However, repeat CT performed after 2 months showed a spontaneous decrease in the tumor size. Exploratory resection revealed non-small cell lung cancer, which was confirmed by the findings of intraoperative frozen-section analysis; therefore, right upper lobectomy and mediastinal lymph node dissection were performed. The postoperative, pathological diagnosis was squamous cell carcinoma arising from the wall of a bulla. From this case, we infer that lung cancer arising from the wall of a bulla may spontaneously regress, and FDG/PET is a useful tool to diagnose lung tumor in patients with pulmonary bullous disease.

Original languageEnglish
Pages (from-to)577-579
Number of pages3
JournalAnnals of Thoracic and Cardiovascular Surgery
Issue number6
Publication statusPublished - 2011



  • Bulla
  • Lung cancer
  • PET-CT
  • Spontaneous regression

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Gastroenterology

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