TY - JOUR
T1 - Spontaneous regression of plasmablastic lymphoma in an elderly human immunodeficiency virus (HIV)-negative patient
AU - Igawa, Takuro
AU - Sato, Yasuharu
AU - Kawai, Hotaka
AU - Kondo, Eisei
AU - Takeuchi, Mai
AU - Miyata-Takata, Tomoko
AU - Takata, Katsuyoshi
AU - Yoshino, Tadashi
N1 - Funding Information:
This work was supported in part by a Grant for Intractable Diseases (IgG4-related disease research program) from the Ministry of Health, Labor and Welfare in Japan.
Publisher Copyright:
© 2015 Igawa et al.
PY - 2015/10/6
Y1 - 2015/10/6
N2 - Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with human immunodeficiency virus (HIV) infection. Herein we describe a rare case of PBL that spontaneously regressed. An 80-year-old man was referred to our hospital owing to an exophytic gingival tumor in the right maxillary second molar region. He had no significant past medical history, and a screening test for HIV was negative. Imaging showed that the tumor measured 26 × 23 × 16 mm and was confined in the alveolar bone. The tumor was histologically comprised of highly proliferative immunoblastic cells positive for CD138 and Epstein-Barr virus (EBV)-encoded RNA. Monoclonal IgH chain gene rearrangement was detected via polymerase chain reaction. After biopsy and diagnosis of PBL, the tumor began to decrease in size and had apparently disappeared at the time of surgery. There was no histological evidence of a residual lesion in the surgical specimen. In conclusion, a minority of immunosenescence-associated PBLs in the elderly should be recognized as a unique clinicopathological entity distinct from common aggressive PBL.
AB - Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with human immunodeficiency virus (HIV) infection. Herein we describe a rare case of PBL that spontaneously regressed. An 80-year-old man was referred to our hospital owing to an exophytic gingival tumor in the right maxillary second molar region. He had no significant past medical history, and a screening test for HIV was negative. Imaging showed that the tumor measured 26 × 23 × 16 mm and was confined in the alveolar bone. The tumor was histologically comprised of highly proliferative immunoblastic cells positive for CD138 and Epstein-Barr virus (EBV)-encoded RNA. Monoclonal IgH chain gene rearrangement was detected via polymerase chain reaction. After biopsy and diagnosis of PBL, the tumor began to decrease in size and had apparently disappeared at the time of surgery. There was no histological evidence of a residual lesion in the surgical specimen. In conclusion, a minority of immunosenescence-associated PBLs in the elderly should be recognized as a unique clinicopathological entity distinct from common aggressive PBL.
KW - Immunosenescence
KW - Plasmablastic lymphoma
KW - Spontaneous regression
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U2 - 10.1186/s13000-015-0421-y
DO - 10.1186/s13000-015-0421-y
M3 - Article
C2 - 26445485
AN - SCOPUS:84943663121
SN - 1746-1596
VL - 10
JO - Diagnostic Pathology
JF - Diagnostic Pathology
IS - 1
M1 - 183
ER -
