Spontaneous regression of plasmablastic lymphoma in an elderly human immunodeficiency virus (HIV)-negative patient

Takuro Igawa, Yasuharu Sato, Hotaka Kawai, Eisei Kondo, Mai Takeuchi, Tomoko Miyata-Takata, Katsuyoshi Takata, Tadashi Yoshino

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with human immunodeficiency virus (HIV) infection. Herein we describe a rare case of PBL that spontaneously regressed. An 80-year-old man was referred to our hospital owing to an exophytic gingival tumor in the right maxillary second molar region. He had no significant past medical history, and a screening test for HIV was negative. Imaging showed that the tumor measured 26 × 23 × 16 mm and was confined in the alveolar bone. The tumor was histologically comprised of highly proliferative immunoblastic cells positive for CD138 and Epstein-Barr virus (EBV)-encoded RNA. Monoclonal IgH chain gene rearrangement was detected via polymerase chain reaction. After biopsy and diagnosis of PBL, the tumor began to decrease in size and had apparently disappeared at the time of surgery. There was no histological evidence of a residual lesion in the surgical specimen. In conclusion, a minority of immunosenescence-associated PBLs in the elderly should be recognized as a unique clinicopathological entity distinct from common aggressive PBL.

Original languageEnglish
Article number183
JournalDiagnostic Pathology
Volume10
Issue number1
DOIs
Publication statusPublished - Oct 6 2015

Fingerprint

HIV
Neoplasms
Gene Rearrangement
Virus Diseases
Human Herpesvirus 4
Lymphoma
RNA
Biopsy
Bone and Bones
Polymerase Chain Reaction
Plasmablastic Lymphoma
Immunosenescence

Keywords

  • Immunosenescence
  • Plasmablastic lymphoma
  • Spontaneous regression

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Spontaneous regression of plasmablastic lymphoma in an elderly human immunodeficiency virus (HIV)-negative patient. / Igawa, Takuro; Sato, Yasuharu; Kawai, Hotaka; Kondo, Eisei; Takeuchi, Mai; Miyata-Takata, Tomoko; Takata, Katsuyoshi; Yoshino, Tadashi.

In: Diagnostic Pathology, Vol. 10, No. 1, 183, 06.10.2015.

Research output: Contribution to journalArticle

@article{f4e06385071e47d7affb0cc75ba43b89,
title = "Spontaneous regression of plasmablastic lymphoma in an elderly human immunodeficiency virus (HIV)-negative patient",
abstract = "Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with human immunodeficiency virus (HIV) infection. Herein we describe a rare case of PBL that spontaneously regressed. An 80-year-old man was referred to our hospital owing to an exophytic gingival tumor in the right maxillary second molar region. He had no significant past medical history, and a screening test for HIV was negative. Imaging showed that the tumor measured 26 × 23 × 16 mm and was confined in the alveolar bone. The tumor was histologically comprised of highly proliferative immunoblastic cells positive for CD138 and Epstein-Barr virus (EBV)-encoded RNA. Monoclonal IgH chain gene rearrangement was detected via polymerase chain reaction. After biopsy and diagnosis of PBL, the tumor began to decrease in size and had apparently disappeared at the time of surgery. There was no histological evidence of a residual lesion in the surgical specimen. In conclusion, a minority of immunosenescence-associated PBLs in the elderly should be recognized as a unique clinicopathological entity distinct from common aggressive PBL.",
keywords = "Immunosenescence, Plasmablastic lymphoma, Spontaneous regression",
author = "Takuro Igawa and Yasuharu Sato and Hotaka Kawai and Eisei Kondo and Mai Takeuchi and Tomoko Miyata-Takata and Katsuyoshi Takata and Tadashi Yoshino",
year = "2015",
month = "10",
day = "6",
doi = "10.1186/s13000-015-0421-y",
language = "English",
volume = "10",
journal = "Diagnostic Pathology",
issn = "1746-1596",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Spontaneous regression of plasmablastic lymphoma in an elderly human immunodeficiency virus (HIV)-negative patient

AU - Igawa, Takuro

AU - Sato, Yasuharu

AU - Kawai, Hotaka

AU - Kondo, Eisei

AU - Takeuchi, Mai

AU - Miyata-Takata, Tomoko

AU - Takata, Katsuyoshi

AU - Yoshino, Tadashi

PY - 2015/10/6

Y1 - 2015/10/6

N2 - Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with human immunodeficiency virus (HIV) infection. Herein we describe a rare case of PBL that spontaneously regressed. An 80-year-old man was referred to our hospital owing to an exophytic gingival tumor in the right maxillary second molar region. He had no significant past medical history, and a screening test for HIV was negative. Imaging showed that the tumor measured 26 × 23 × 16 mm and was confined in the alveolar bone. The tumor was histologically comprised of highly proliferative immunoblastic cells positive for CD138 and Epstein-Barr virus (EBV)-encoded RNA. Monoclonal IgH chain gene rearrangement was detected via polymerase chain reaction. After biopsy and diagnosis of PBL, the tumor began to decrease in size and had apparently disappeared at the time of surgery. There was no histological evidence of a residual lesion in the surgical specimen. In conclusion, a minority of immunosenescence-associated PBLs in the elderly should be recognized as a unique clinicopathological entity distinct from common aggressive PBL.

AB - Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with human immunodeficiency virus (HIV) infection. Herein we describe a rare case of PBL that spontaneously regressed. An 80-year-old man was referred to our hospital owing to an exophytic gingival tumor in the right maxillary second molar region. He had no significant past medical history, and a screening test for HIV was negative. Imaging showed that the tumor measured 26 × 23 × 16 mm and was confined in the alveolar bone. The tumor was histologically comprised of highly proliferative immunoblastic cells positive for CD138 and Epstein-Barr virus (EBV)-encoded RNA. Monoclonal IgH chain gene rearrangement was detected via polymerase chain reaction. After biopsy and diagnosis of PBL, the tumor began to decrease in size and had apparently disappeared at the time of surgery. There was no histological evidence of a residual lesion in the surgical specimen. In conclusion, a minority of immunosenescence-associated PBLs in the elderly should be recognized as a unique clinicopathological entity distinct from common aggressive PBL.

KW - Immunosenescence

KW - Plasmablastic lymphoma

KW - Spontaneous regression

UR - http://www.scopus.com/inward/record.url?scp=84943663121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943663121&partnerID=8YFLogxK

U2 - 10.1186/s13000-015-0421-y

DO - 10.1186/s13000-015-0421-y

M3 - Article

VL - 10

JO - Diagnostic Pathology

JF - Diagnostic Pathology

SN - 1746-1596

IS - 1

M1 - 183

ER -