Spectrophotometric determination of quinine and its related drugs with o-sulfophenylfluorone and copper(II)

Chikako Yamazaki, Hiroshi Tominaga, Megumi Samma, Rie Isono, Shinichiro Kamino, Takako Yamaguchi, Yoshikazu Fujita

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A novel spectrophotometric method was established for the determination of quinine and its related drugs based on ternary complex formation among o-sulfophenylfluorone, copper(II) and quinine. In the determination of quinine, Beer's low is obeyed in the range of 0.2-3.2 μg cm -3. The effective molar absorptivity at 590 nm and the relative standard deviation were 2.0×10 5 dm 3 mol -1 cm -1 and 2.0% (n = 6), respectively. The method was successfully applied to assays of quinine and its related drugs in pharmaceutical preparations. In addition, it was suggested that the ternary complex showed thermochromism.

Original languageEnglish
Pages (from-to)879-884
Number of pages6
JournalBUNSEKI KAGAKU
Volume56
Issue number10
DOIs
Publication statusPublished - Dec 17 2007

Keywords

  • Quinine and its related drugs
  • Spectrophotometry
  • Ternary complex
  • Thermochromism
  • o-sulfophenylfluorone and copper(II)

ASJC Scopus subject areas

  • Analytical Chemistry

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    Yamazaki, C., Tominaga, H., Samma, M., Isono, R., Kamino, S., Yamaguchi, T., & Fujita, Y. (2007). Spectrophotometric determination of quinine and its related drugs with o-sulfophenylfluorone and copper(II). BUNSEKI KAGAKU, 56(10), 879-884. https://doi.org/10.2116/bunsekikagaku.56.879