A novel spectrophotometric method was established for the determination of quinine and its related drugs based on ternary complex formation among o-sulfophenylfluorone, copper(II) and quinine. In the determination of quinine, Beer's low is obeyed in the range of 0.2-3.2 μg cm -3. The effective molar absorptivity at 590 nm and the relative standard deviation were 2.0×10 5 dm 3 mol -1 cm -1 and 2.0% (n = 6), respectively. The method was successfully applied to assays of quinine and its related drugs in pharmaceutical preparations. In addition, it was suggested that the ternary complex showed thermochromism.
- o-sulfophenylfluorone and copper(II)
- Quinine and its related drugs
- Ternary complex
ASJC Scopus subject areas
- Analytical Chemistry