Spectrophotometric determination of chlorpromazine in preparation with o-sulfophenylfluorone and Gallium(III)

Naoko Suzaki; Shinya Kadi; Kanako Miyachi; Kenzo Moriyama; Shinichiro Kamino; Takako Yamaguchi; Yoshikazu Fujita

doi:10.2116/bunsekikagaku.59.727

Spectrophotometric determination of chlorpromazine in preparation with o-sulfophenylfluorone and Gallium(III)

Naoko Suzaki, Shinya Kadi, Kanako Miyachi, Kenzo Moriyama, Shinichiro Kamino, Takako Yamaguchi, Yoshikazu Fujita

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A novel spectrophotometric method was established for the determination of chlorpromazine (CP) and other drugs with an o-sulfophenylfluorone-gallium(III) complex. In the determination of CP, Beer's law is obeyed in the range of 0.08~2.0 μg/mL. The molar absorptivity and the relative standard deviation were 1.2×10⁵ dm³ mol^-1 cm^-1 and 2.5% (n = 5), respectivery. Moreover, the method was successfully applied to assays of CP and other drugs in pharmaceutical preparations. The proposed method should be useful for simple and sensitive determinations of CP and other drugs.

Original language	English
Pages (from-to)	727-732
Number of pages	6
Journal	BUNSEKI KAGAKU
Volume	59
Issue number	8
DOIs	https://doi.org/10.2116/bunsekikagaku.59.727
Publication status	Published - 2010

Keywords

Chlorpromazine
O-sulfophenylfluorone-gallium(III)-complex
Spectrophotometry

ASJC Scopus subject areas

Analytical Chemistry

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abstract = "A novel spectrophotometric method was established for the determination of chlorpromazine (CP) and other drugs with an o-sulfophenylfluorone-gallium(III) complex. In the determination of CP, Beer's law is obeyed in the range of 0.08~2.0 μg/mL. The molar absorptivity and the relative standard deviation were 1.2×105 dm3 mol-1 cm-1 and 2.5% (n = 5), respectivery. Moreover, the method was successfully applied to assays of CP and other drugs in pharmaceutical preparations. The proposed method should be useful for simple and sensitive determinations of CP and other drugs.",

keywords = "Chlorpromazine, O-sulfophenylfluorone-gallium(III)-complex, Spectrophotometry",

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AU - Suzaki, Naoko

AU - Kadi, Shinya

AU - Miyachi, Kanako

AU - Moriyama, Kenzo

AU - Kamino, Shinichiro

AU - Yamaguchi, Takako

AU - Fujita, Yoshikazu

PY - 2010

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