Spectrophotometric determination of chlorpromazine in preparation with o-sulfophenylfluorone and Gallium(III)

Naoko Suzaki, Shinya Kadi, Kanako Miyachi, Kenzo Moriyama, Shinichiro Kamino, Takako Yamaguchi, Yoshikazu Fujita

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1 Citation (Scopus)

Abstract

A novel spectrophotometric method was established for the determination of chlorpromazine (CP) and other drugs with an o-sulfophenylfluorone-gallium(III) complex. In the determination of CP, Beer's law is obeyed in the range of 0.08~2.0 μg/mL. The molar absorptivity and the relative standard deviation were 1.2×105 dm3 mol-1 cm-1 and 2.5% (n = 5), respectivery. Moreover, the method was successfully applied to assays of CP and other drugs in pharmaceutical preparations. The proposed method should be useful for simple and sensitive determinations of CP and other drugs.

Original languageEnglish
Pages (from-to)727-732
Number of pages6
JournalBUNSEKI KAGAKU
Volume59
Issue number8
DOIs
Publication statusPublished - Nov 19 2010

Keywords

  • Chlorpromazine
  • O-sulfophenylfluorone-gallium(III)-complex
  • Spectrophotometry

ASJC Scopus subject areas

  • Analytical Chemistry

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    Suzaki, N., Kadi, S., Miyachi, K., Moriyama, K., Kamino, S., Yamaguchi, T., & Fujita, Y. (2010). Spectrophotometric determination of chlorpromazine in preparation with o-sulfophenylfluorone and Gallium(III). BUNSEKI KAGAKU, 59(8), 727-732. https://doi.org/10.2116/bunsekikagaku.59.727