Spectrophotometric determination of chlorpromazine and its related drugs by ternary complex formation with o-sulfophenylfluorone-molybdenum(VI)

Chikako Yamazaki; Naoko Suzaki; Masahiro Nakao; Shinichiro Kamino; Takako Yamaguchi; Yoshikazu Fujita

doi:10.2116/bunsekikagaku.55.733

Spectrophotometric determination of chlorpromazine and its related drugs by ternary complex formation with o-sulfophenylfluorone-molybdenum(VI)

Chikako Yamazaki, Naoko Suzaki, Masahiro Nakao, Shinichiro Kamino, Takako Yamaguchi, Yoshikazu Fujita

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A novel spectrophotometric method was established for the determination of chlorpromazine (CPZ) and its related drugs. The method is based on ternary complex formation among o-sulfophenylfluorone, molybdenum(VI) and CPZ. In the determination of CPZ, Beer's law is obeyed in the range of 0.2-7.0 μg ml ^-1. The effective molar absorptivity at 525 nm and the relative standard deviation were 4.6 × 10⁴ dm³ mol ^-1 cm^-1 and 2.4% (n = 6), respectively. The method was successfully applied to assays of CPZ and its related drugs in pharmaceutical preparations. The proposed method, requiring no solvent extraction, should be useful for a simple and sensitive determination of CPZ and its related drugs.

Original language	English
Pages (from-to)	733-737
Number of pages	5
Journal	BUNSEKI KAGAKU
Volume	55
Issue number	9
DOIs	https://doi.org/10.2116/bunsekikagaku.55.733
Publication status	Published - 2006

Keywords

Chlorpromazine
Chlorpromazine related drugs
Spectrophotometry
Ternary complex formation
o-sulfophenylfluorone-molybdenum(VI)

ASJC Scopus subject areas

Analytical Chemistry

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title = "Spectrophotometric determination of chlorpromazine and its related drugs by ternary complex formation with o-sulfophenylfluorone-molybdenum(VI)",

abstract = "A novel spectrophotometric method was established for the determination of chlorpromazine (CPZ) and its related drugs. The method is based on ternary complex formation among o-sulfophenylfluorone, molybdenum(VI) and CPZ. In the determination of CPZ, Beer's law is obeyed in the range of 0.2-7.0 μg ml -1. The effective molar absorptivity at 525 nm and the relative standard deviation were 4.6 × 104 dm3 mol -1 cm-1 and 2.4% (n = 6), respectively. The method was successfully applied to assays of CPZ and its related drugs in pharmaceutical preparations. The proposed method, requiring no solvent extraction, should be useful for a simple and sensitive determination of CPZ and its related drugs.",

keywords = "Chlorpromazine, Chlorpromazine related drugs, Spectrophotometry, Ternary complex formation, o-sulfophenylfluorone-molybdenum(VI)",

author = "Chikako Yamazaki and Naoko Suzaki and Masahiro Nakao and Shinichiro Kamino and Takako Yamaguchi and Yoshikazu Fujita",

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doi = "10.2116/bunsekikagaku.55.733",

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T1 - Spectrophotometric determination of chlorpromazine and its related drugs by ternary complex formation with o-sulfophenylfluorone-molybdenum(VI)

AU - Yamazaki, Chikako

AU - Suzaki, Naoko

AU - Nakao, Masahiro

AU - Kamino, Shinichiro

AU - Yamaguchi, Takako

AU - Fujita, Yoshikazu

PY - 2006

Y1 - 2006

N2 - A novel spectrophotometric method was established for the determination of chlorpromazine (CPZ) and its related drugs. The method is based on ternary complex formation among o-sulfophenylfluorone, molybdenum(VI) and CPZ. In the determination of CPZ, Beer's law is obeyed in the range of 0.2-7.0 μg ml -1. The effective molar absorptivity at 525 nm and the relative standard deviation were 4.6 × 104 dm3 mol -1 cm-1 and 2.4% (n = 6), respectively. The method was successfully applied to assays of CPZ and its related drugs in pharmaceutical preparations. The proposed method, requiring no solvent extraction, should be useful for a simple and sensitive determination of CPZ and its related drugs.

AB - A novel spectrophotometric method was established for the determination of chlorpromazine (CPZ) and its related drugs. The method is based on ternary complex formation among o-sulfophenylfluorone, molybdenum(VI) and CPZ. In the determination of CPZ, Beer's law is obeyed in the range of 0.2-7.0 μg ml -1. The effective molar absorptivity at 525 nm and the relative standard deviation were 4.6 × 104 dm3 mol -1 cm-1 and 2.4% (n = 6), respectively. The method was successfully applied to assays of CPZ and its related drugs in pharmaceutical preparations. The proposed method, requiring no solvent extraction, should be useful for a simple and sensitive determination of CPZ and its related drugs.

KW - Chlorpromazine

KW - Chlorpromazine related drugs

KW - Spectrophotometry

KW - Ternary complex formation

KW - o-sulfophenylfluorone-molybdenum(VI)

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DO - 10.2116/bunsekikagaku.55.733

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SN - 0525-1931

VL - 55

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JO - Bunseki Kagaku

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IS - 9

ER -

Spectrophotometric determination of chlorpromazine and its related drugs by ternary complex formation with o-sulfophenylfluorone-molybdenum(VI)

Abstract

Keywords

ASJC Scopus subject areas

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