Spectrophotometric determination of chlorpromazine and its related drugs by ternary complex formation with o-sulfophenylfluorone-molybdenum(VI)

Chikako Yamazaki, Naoko Suzaki, Masahiro Nakao, Shinichiro Kamino, Takako Yamaguchi, Yoshikazu Fujita

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8 Citations (Scopus)

Abstract

A novel spectrophotometric method was established for the determination of chlorpromazine (CPZ) and its related drugs. The method is based on ternary complex formation among o-sulfophenylfluorone, molybdenum(VI) and CPZ. In the determination of CPZ, Beer's law is obeyed in the range of 0.2-7.0 μg ml -1. The effective molar absorptivity at 525 nm and the relative standard deviation were 4.6 × 104 dm3 mol -1 cm-1 and 2.4% (n = 6), respectively. The method was successfully applied to assays of CPZ and its related drugs in pharmaceutical preparations. The proposed method, requiring no solvent extraction, should be useful for a simple and sensitive determination of CPZ and its related drugs.

Original languageEnglish
Pages (from-to)733-737
Number of pages5
JournalBUNSEKI KAGAKU
Volume55
Issue number9
DOIs
Publication statusPublished - Nov 27 2006

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Keywords

  • Chlorpromazine
  • Chlorpromazine related drugs
  • Spectrophotometry
  • Ternary complex formation
  • o-sulfophenylfluorone-molybdenum(VI)

ASJC Scopus subject areas

  • Analytical Chemistry

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