Spectral characteristics of EEG gamma rhythms associated with epileptic spasms

Takushi Inoue, Katsuhiro Kobayashi, Makio Oka, Harumi Yoshinaga, Yoko Ohtsuka

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

To elucidate the pathophysiology of epileptic spasms, unaveraged time-frequency spectra of spasm-associated EEG gamma rhythms were investigated in 15 patients with West syndrome or related disorders. Using these unaveraged spectra, we were able to investigate in detail various aspects of the structure of ictal gamma rhythms that could not be examined using averaged spectra. The characteristics of the ictal gamma peaks (peak frequency, power, duration, and the number of peaks in each brain-region for each spasm) were statistically evaluated with respect to their differences among the brain regions and over the time-course of the clusters. Our findings were as follows: (1) Gamma peaks were clearly detected in most spectra and generally had a similar pattern in each spasm, which repeated in clusters. (2) The mean frequency of gamma peaks was 69.2 ± 16.8 Hz, and the number of peaks in each brain region of each spasm was 1.83 ± 1.16. (3) The occipitoparietal gamma peaks had significantly greater power and longer duration than the frontocentral peaks. (4) The frequency of the gamma peaks was higher in the mid phase of clusters than in the ending, and it tended to have a positive correlation with its latency from the preceding beta peak. An analysis of the ictal gamma rhythms might give some insight into the generative mechanism of spasms.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalBrain and Development
Volume30
Issue number5
DOIs
Publication statusPublished - May 2008

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Spasm
Electroencephalography
Stroke
Brain
Infantile Spasms
Gamma Rhythm

Keywords

  • Gamma rhythm
  • Ictal EEG
  • Power spectrum
  • Spasms
  • Time-frequency analysis
  • West syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Spectral characteristics of EEG gamma rhythms associated with epileptic spasms. / Inoue, Takushi; Kobayashi, Katsuhiro; Oka, Makio; Yoshinaga, Harumi; Ohtsuka, Yoko.

In: Brain and Development, Vol. 30, No. 5, 05.2008, p. 321-328.

Research output: Contribution to journalArticle

Inoue, Takushi ; Kobayashi, Katsuhiro ; Oka, Makio ; Yoshinaga, Harumi ; Ohtsuka, Yoko. / Spectral characteristics of EEG gamma rhythms associated with epileptic spasms. In: Brain and Development. 2008 ; Vol. 30, No. 5. pp. 321-328.
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