Spectral analysis of EEG gamma rhythms associated with tonic seizures in Lennox-Gastaut syndrome

Katsuhiro Kobayashi, Takushi Inoue, Yoshiaki Watanabe, Makio Oka, Fumika Endoh, Harumi Yoshinaga, Yoko Ohtsuka

Research output: Contribution to journalArticle

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Abstract

Purpose: EEG gamma rhythms, which are found in association with epileptic spasms in infants with West syndrome, were explored in the ictal EEGs of tonic seizures in older patients with Lennox-Gastaut syndrome (LGS) to investigate the pathophysiology of the disease. Methods: The subjects were 20 patients with LGS (11 males, 9 females; age range: 3 years 1 month to 29 years 3 months) who had at least one digitally recorded tonic seizure with minimal artifacts. A time-frequency analysis was applied to each patient's ictal EEG data. Results: A total of 54 seizures were analyzed, excluding spasms in clusters. The ictal EEGs of the tonic seizures showed only diffuse desynchronization in 10 seizures, and desynchronization followed by rhythmic activity in 21. The ictal discharges started as rhythmic activity of varying amplitude without initial desynchronization in 23 seizures. In a total of 25 seizures from 13 patients, gamma rhythms with frequencies ranging from 43 to 101.6 Hz were detected by temporal expansion of the ictal EEG traces and spectral analysis. In 24 (96%) of these seizures, gamma rhythms were observed at seizure onset corresponding to visually identified desynchronization. In the remaining seizure, gamma rhythms were found in association with transient suppression of high-amplitude rapid discharges. Conclusion: The detection of gamma rhythms in the ictal EEGs of tonic seizures indicated that some tonic seizures might have generative mechanisms in common with epileptic spasms, and that these mechanisms are possibly related to desynchronization at seizure onset.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalEpilepsy Research
Volume86
Issue number1
DOIs
Publication statusPublished - Sep 2009

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Electroencephalography
Seizures
Stroke
Spasm
Lennox Gastaut Syndrome
Gamma Rhythm
Infantile Spasms
Artifacts

Keywords

  • Gamma rhythm
  • High-frequency oscillation
  • Ictal EEG
  • Lennox-Gastaut syndrome
  • Time-frequency analysis
  • Tonic seizure

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Spectral analysis of EEG gamma rhythms associated with tonic seizures in Lennox-Gastaut syndrome. / Kobayashi, Katsuhiro; Inoue, Takushi; Watanabe, Yoshiaki; Oka, Makio; Endoh, Fumika; Yoshinaga, Harumi; Ohtsuka, Yoko.

In: Epilepsy Research, Vol. 86, No. 1, 09.2009, p. 15-22.

Research output: Contribution to journalArticle

Kobayashi, Katsuhiro ; Inoue, Takushi ; Watanabe, Yoshiaki ; Oka, Makio ; Endoh, Fumika ; Yoshinaga, Harumi ; Ohtsuka, Yoko. / Spectral analysis of EEG gamma rhythms associated with tonic seizures in Lennox-Gastaut syndrome. In: Epilepsy Research. 2009 ; Vol. 86, No. 1. pp. 15-22.
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