Specific removal of monocytes from peripheral blood of septic patients by polymyxin B-immobilized filter column

Masahiro Nishibori, Hideo K. Takahashi, Hiroshi Katayama, Shuji Mori, Shinya Saito, Hiromi Iwagaki, Noriaki Tanakac, Kiyoshi Morita, Aiji Ohtsuka

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Lipopolysaccharide (LPS) is one of the major causes of septic shock. The polymyxin B-immobilized filter column (PMX) was developed for the adsorption of endotoxin by direct hemoperfusion and has been used for the treatment of LPS-induced septic shock. In this study, we demonstrated that PMX also specifically bound monocytes from the peripheral blood leukocytes of septic patients by mean of an analysis of bound cells using immunocytochemical and electron microscopic techniques. The specific removal of monocytes from septic patients may produce beneficial effects by reducing the interaction between monocytes and functionally associated cells including vascular endothelial cells.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalActa medica Okayama
Volume63
Issue number1
Publication statusPublished - Feb 1 2009

Keywords

  • Adsorptive removal
  • Monocyte
  • Polymixin B-immobilized column
  • Septic shock

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Specific removal of monocytes from peripheral blood of septic patients by polymyxin B-immobilized filter column'. Together they form a unique fingerprint.

  • Cite this